Activating Compound | Comment | Organism | Structure |
---|---|---|---|
isoproterenol | activates | Bos taurus | |
phorbol 12,13-dibutyrate | activates | Bos taurus | |
protein kinase A | phosphorylates and activates IP3K | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | at concentrations higher than 0.01-0.1 mM | Bos taurus | |
Protein kinase C | phosphorylates and inactivates enzyme | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00056 | - |
1D-myo-inositol 1,4,5-trisphosphate | pH 7.2, 37°C, in presence or absence of 50 nM calmodulin | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | predominantly | Bos taurus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | maximal at 0.01-0.1 mM Ca2+, interaction between the Ca2+-calmodulin complex and enzyme | Bos taurus | |
Ca2+ | activation by Ca2+/calmodulin | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, SDS-PAGE | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Bos taurus | role in limiting the availability of InsP3 for Ca2+ release in smooth muscle relaxation | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Bos taurus | inositol phosphate metabolism | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
114fold | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
iris sphincter muscle | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.94 | - |
pH 7.2, 37°C | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | specific for phosphorylation of the 3-position | Bos taurus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | role in limiting the availability of InsP3 for Ca2+ release in smooth muscle relaxation | Bos taurus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | inositol phosphate metabolism | Bos taurus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, SDS-PAGE | Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 7.5 | - |
Bos taurus |
7.2 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Bos taurus | |
Calmodulin | activation by Ca2+/calmodulin | Bos taurus | |
Calmodulin | maximal at 50 nM calmodulin, reversed by EGTA, interaction between the Ca2+-calmodulin complex and enzyme | Bos taurus |