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Literature summary for 2.7.1.127 extracted from

  • Yamaguchi, K.; Hirata, M.; Kuriyama, H.
    Calmodulin activates inositol 1,4,5-trisphosphate 3-kinase activity in pig aortic smooth muscle (1987), Biochem. J., 244, 787-791.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.127

Inhibitors

Inhibitors Comment Organism Structure
chlorpromazine calmodulin-antagonist, inhibits Ca2+-activated enzyme activity Sus scrofa
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide i.e. W-7, calmodulin-antagonist; inhibits Ca2+-activated enzyme activity Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Sus scrofa 5829
-
soluble
-
 Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ effects of Ca2+/calmodulin on enzyme activity, the calmodulin antagonists W-7 or chlorpromazine inhibit the Ca2+-enhancement of enzyme activity Sus scrofa
Ca2+ at physiological concentrations Sus scrofa
Ca2+ activation by Ca2+/calmodulin Sus scrofa
Mg2+
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Sus scrofa inositol 1,4,5-trisphosphate is a second messenger ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
aorta smooth muscle Sus scrofa
-
smooth muscle aortic Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Sus scrofa ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate inositol 1,4,5-trisphosphate is a second messenger Sus scrofa ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Sus scrofa
Calmodulin effects of Ca2+/calmodulin on enzyme activity Sus scrofa
Calmodulin activation by Ca2+/calmodulin Sus scrofa