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Literature summary for 2.7.1.113 extracted from
- Gene duplications and losses among vertebrate deoxyribonucleoside kinases of the non-TK1 family (2016), Nucleosides Nucleotides Nucleic Acids, 35, 677-690 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0005 | - |
deoxyguanosine | at pH 8.0, temperature not specified in the publication | Xenopus laevis |  |
| 2.689 | - |
deoxyadenosine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 4.424 | - |
deoxycytidine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 10.624 | - |
deoxyuridine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 201.859 | - |
deoxythymidine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Xenopus laevis | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 2.5 mM used in assay conditions | Xenopus laevis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + deoxyguanosine | Xenopus laevis | - |
ADP + dGMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| no activity in Gallus gallus | - |
- |
- |
| Xenopus laevis | Q6GPW6 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + deoxyadenosine | - |
Xenopus laevis | ADP + dAMP | - |
? | |
| ATP + deoxycytidine | - |
Xenopus laevis | ADP + dCMP | - |
? | |
| ATP + deoxyguanosine | - |
Xenopus laevis | ADP + dGMP | - |
? | |
| ATP + deoxyguanosine | highest activity | Xenopus laevis | ADP + dGMP | - |
? | |
| ATP + deoxythymidine | lowest activity | Xenopus laevis | ADP + dTMP | - |
? | |
| ATP + deoxyuridine | - |
Xenopus laevis | ADP + dUMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DGK | - |
Xenopus laevis |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
deoxyuridine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 0.07 | - |
deoxythymidine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 0.11 | - |
deoxyguanosine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 0.3 | - |
deoxyadenosine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 0.51 | - |
deoxycytidine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000358 | - |
deoxythymidine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 0.00196 | - |
deoxyuridine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 0.11 | - |
deoxyadenosine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 0.115 | - |
deoxycytidine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
| 227 | - |
deoxyguanosine | at pH 8.0, temperature not specified in the publication | Xenopus laevis | |
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