Literature summary for 2.7.1.113 extracted from

Petrakis, T.G.; Ktistaki, E.; Wang, L.; Eriksson, S.; Talianidis, I.
Cloning and characterization of mouse deoxyguanosine kinase. Evidence for a cytoplasmic isoform (1999), J. Biol. Chem., 274, 24726-24730.

Search for more literature for 2.7.1.113

Cloned(Commentary)

Cloned (Comment)	Organism
expression of His-tagged deoxyguanosine kinase in Escherichia coli	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	deoxyguanosine kinase 2	Mus musculus	5829	-
mitochondrion	-	Mus musculus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9QX60	mitochondrial deoxyguanosine kinase 1	-
Mus musculus	Q9QX60	cytosolic deoxyguanosine kinase 2, amino-terminally truncated isoform	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	low expression levels	Mus musculus	-
liver	low expression	Mus musculus	-
spleen	high expression levels	Mus musculus	-
thymus	high expression	Mus musculus	-
thymus	high expression levels	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 2',2'-difluorodeoxyguanosine	recombinant mitochondrial deoxyguanosine kinase, 147% of activity with deoxyguanosine	Mus musculus	ADP + 2',2'-difluorodeoxyguanosine 5'-monophosphate	-	?
ATP + 2-chloro-2'-deoxyadenosine	recombinant mitochondrial deoxyguanosine kinase, 200% of activity with deoxyguanosine at 0.005 mM	Mus musculus	ADP + 2-chloro-2'-deoxyadenosine monophosphate	-	?
ATP + deoxyadenosine	recombinant mitochondrial deoxyguanosine kinase, very low activity	Mus musculus	ADP + dAMP	-	?
ATP + deoxyguanosine	-	Mus musculus	ADP + dGMP	-	?
ATP + deoxyinosine	10% of activity with deoxyguanosine	Mus musculus	ADP + dIMP	-	?

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Release 2023.1 (January 2023)