BRENDA - Enzyme Database
show all sequences of 2.7.1.113

Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs

Sjoberg, A.H.; Wang, L.; Eriksson, S.; Mol. Pharmacol. 53, 270-273 (1998)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.004
-
deoxyguanosine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.012
-
deoxyinosine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.033
-
arabinosyl guanine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.056
-
2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.078
-
2-chloro-2'-deoxyadenosine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.34
-
deoxycytidine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.46
-
2-fluoro-arabinosyl-adenine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.47
-
deoxyadenosine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + deoxyinosine
Homo sapiens
recombinant mitochondrial deoxyguanosine kinase, may be the preferred substrate in vivo
ADP + dIMP
-
Homo sapiens
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
recombinant enzyme, metal affinity chromatography
Homo sapiens
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.04
0.05
recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine 5'-monophosphate
-
640555
Homo sapiens
?
ATP + 2-chloro-2'-deoxyadenosine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + 2-chloro-2'-deoxyadenosine monophosphate
-
640555
Homo sapiens
?
ATP + 2-fluoro-arabinosyl-adenine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + 2-fluoro-arabinosyl-adenine 5'-monophosphate
-
640555
Homo sapiens
?
ATP + arabinosyl adenine
recombinant mitochondrial deoxyguanosine kinase, very low activity
640555
Homo sapiens
ADP + arabinosyl adenine 5'-monophosphate
-
640555
Homo sapiens
?
ATP + arabinosyl guanine
recombinant mitochondrial deoxyguanosine kinase, better substrate than deoxyguanosine kinase
640555
Homo sapiens
ADP + arabinosyl guanine 5'-monophosphate
-
640555
Homo sapiens
?
ATP + deoxyadenosine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + dAMP
-
640555
Homo sapiens
?
ATP + deoxycytidine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + dCMP
-
640555
Homo sapiens
?
ATP + deoxyinosine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + dIMP
-
640555
Homo sapiens
?
ATP + deoxyinosine
recombinant mitochondrial deoxyguanosine kinase, may be the preferred substrate in vivo
640555
Homo sapiens
ADP + dIMP
-
640555
Homo sapiens
?
ATP + dideoxyinosine
recombinant mitochondrial deoxyguanosine kinase, very low activity
640555
Homo sapiens
ADP + dideoxyinosine 5'-monophosphate
-
640555
Homo sapiens
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.004
-
deoxyguanosine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.012
-
deoxyinosine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.033
-
arabinosyl guanine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.056
-
2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.078
-
2-chloro-2'-deoxyadenosine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.34
-
deoxycytidine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.46
-
2-fluoro-arabinosyl-adenine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
0.47
-
deoxyadenosine
pH 7.6, recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + deoxyinosine
Homo sapiens
recombinant mitochondrial deoxyguanosine kinase, may be the preferred substrate in vivo
ADP + dIMP
-
Homo sapiens
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant enzyme, metal affinity chromatography
Homo sapiens
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.04
0.05
recombinant mitochondrial deoxyguanosine kinase
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine 5'-monophosphate
-
640555
Homo sapiens
?
ATP + 2-chloro-2'-deoxyadenosine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + 2-chloro-2'-deoxyadenosine monophosphate
-
640555
Homo sapiens
?
ATP + 2-fluoro-arabinosyl-adenine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + 2-fluoro-arabinosyl-adenine 5'-monophosphate
-
640555
Homo sapiens
?
ATP + arabinosyl adenine
recombinant mitochondrial deoxyguanosine kinase, very low activity
640555
Homo sapiens
ADP + arabinosyl adenine 5'-monophosphate
-
640555
Homo sapiens
?
ATP + arabinosyl guanine
recombinant mitochondrial deoxyguanosine kinase, better substrate than deoxyguanosine kinase
640555
Homo sapiens
ADP + arabinosyl guanine 5'-monophosphate
-
640555
Homo sapiens
?
ATP + deoxyadenosine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + dAMP
-
640555
Homo sapiens
?
ATP + deoxycytidine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + dCMP
-
640555
Homo sapiens
?
ATP + deoxyinosine
recombinant mitochondrial deoxyguanosine kinase
640555
Homo sapiens
ADP + dIMP
-
640555
Homo sapiens
?
ATP + deoxyinosine
recombinant mitochondrial deoxyguanosine kinase, may be the preferred substrate in vivo
640555
Homo sapiens
ADP + dIMP
-
640555
Homo sapiens
?
ATP + dideoxyinosine
recombinant mitochondrial deoxyguanosine kinase, very low activity
640555
Homo sapiens
ADP + dideoxyinosine 5'-monophosphate
-
640555
Homo sapiens
?
Other publictions for EC 2.7.1.113
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738348
Vilarinho
Recurrent recessive mutation i ...
Homo sapiens
Hepatology
63
1977-1986
2016
-
-
-
-
1
-
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1
-
-
1
-
3
-
-
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1
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1
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1
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737913
Li
-
One-pot process of 2-deoxyguan ...
Bacillus subtilis, Bacillus subtilis 168
Biotechnol. Bioprocess Eng.
20
37-43
2015
-
-
1
-
-
-
-
-
-
-
-
4
-
2
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1
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4
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1
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4
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1
-
4
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-
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-
-
-
-
-
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-
-
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-
737461
Sun
Zidovudine induces downregulat ...
Homo sapiens
Antimicrob. Agents Chemother.
58
6758-6766
2014
-
-
-
-
-
-
-
-
1
-
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1
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1
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1
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1
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1
-
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1
-
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737599
Sun
Down-regulation of mitochondri ...
Homo sapiens
Biochem. Biophys. Res. Commun.
450
1021-1026
2014
-
-
-
-
-
-
-
-
1
-
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1
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1
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1
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1
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1
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1
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1
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1
-
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-
-
-
-
-
-
-
1
-
-
1
-
-
723198
Buchaklian
Recessive deoxyguanosine kinas ...
Homo sapiens
Mol. Genet. Metab.
107
92-94
2012
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
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1
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1
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-
-
-
-
-
-
-
-
-
2
2
-
-
-
722470
Pronicka
Post mortem identification of ...
Homo sapiens
J. Appl. Genet.
52
61-66
2011
-
-
-
-
4
-
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2
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-
2
-
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4
-
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-
-
-
-
-
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703966
Dimmock
Clinical and molecular feature ...
Homo sapiens
Hum. Mutat.
29
330-331
2008
-
-
-
-
8
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
8
-
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-
1
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705474
Dimmock
Abnormal neurological features ...
Homo sapiens
Liver Transpl.
14
1480-1485
2008
-
-
-
-
6
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
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6
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705750
Saada
Mitochondrial deoxyribonucleot ...
Homo sapiens
Mol. Genet. Metab.
95
169-173
2008
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
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-
-
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-
1
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1
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-
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-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705997
Fyrberg
RNAi depletion of deoxycytidin ...
Homo sapiens
Nucleosides Nucleotides Nucleic Acids
27
712-719
2008
-
-
-
-
-
-
6
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
671801
Fyrberg
Cell cycle effect on the activ ...
Homo sapiens
Biochem. Biophys. Res. Commun.
357
847-853
2007
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
5
-
-
3
-
-
-
-
-
-
-
-
1
-
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1
-
-
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1
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1
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-
5
-
-
3
-
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-
-
-
-
-
-
-
-
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-
-
-
-
671890
Mousson de Camaret
Kinetic properties of mutant d ...
Homo sapiens
Biochem. J.
402
377-385
2007
-
-
-
-
5
-
-
10
1
-
-
2
-
2
-
-
-
-
-
2
-
1
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
5
-
-
-
-
10
1
-
-
2
-
-
-
-
-
2
-
1
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673472
Franco
Depletion of mitochondrial DNA ...
Homo sapiens
Exp. Cell Res.
313
2687-2694
2007
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
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-
-
1
-
-
1
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-
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1
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1
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1
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675444
Sandrini
Dictyostelium discoideum salva ...
Dictyostelium discoideum
J. Mol. Biol.
369
653-664
2007
-
-
1
-
-
-
-
2
-
-
1
-
-
6
-
-
-
-
-
1
-
-
2
-
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-
-
2
-
-
-
1
-
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-
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-
1
1
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-
-
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-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
671919
Lotfi
The pattern of deoxycytidine- ...
Homo sapiens
Biochem. Pharmacol.
71
882-890
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
5
3
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
3
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661040
Rylova
Activity profiles of deoxynucl ...
Homo sapiens
Biochem. Pharmacol.
69
951-960
2005
-
-
1
-
-
-
-
-
1
1
-
1
-
2
-
-
-
-
-
3
2
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
3
2
-
1
-
-
-
-
-
1
-
-
-
-
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662882
Wang
Molecular insight into mitocho ...
Homo sapiens
Mol. Genet. Metab.
84
75-82
2005
-
-
1
-
1
-
-
9
2
1
-
3
-
2
-
-
-
-
-
2
1
-
5
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
9
2
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