General Stability | Organism |
---|---|
ATP or MgATP2- stabilize, not Mg2+ alone | Mus musculus |
loss of activity in dilute solution | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
deoxyadenosine | 0.07 mM, 9% inhibition | Mus musculus | |
deoxyinosine | 0.07 mM, 17% inhibition | Mus musculus | |
dGDP | 0.1 mM, 97% inhibition | Mus musculus | |
dGMP | - |
Mus musculus | |
dGTP | 0.1 mM, 99% inhibition | Mus musculus | |
dTDP | - |
Mus musculus | |
additional information | not inhibited by deoxyadenosine | Mus musculus | |
UDP | strong inhibition | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
deoxyguanosine | pH 5.2, 37°C | Mus musculus | |
0.023 | - |
ATP | pH 5.2, 37°C, at concentrations below 0.5 mM | Mus musculus | |
0.023 | - |
ATP | ATP in form of MgATP2- | Mus musculus | |
0.63 | - |
ATP | pH 5.2, 37°C, at concentrations above 0.5 mM | Mus musculus | |
0.63 | - |
ATP | ATP in form of MgATP2- | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mus musculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation | Mus musculus | |
Cd2+ | slight activation | Mus musculus | |
Mg2+ | required for activity | Mus musculus | |
Mn2+ | can replace Mg2+ to some extent | Mus musculus | |
Zn2+ | activation, can replace Mg2+ to some extent | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
44000 | - |
glycerol density gradient centrifugation | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxyguanosine | Mus musculus | first reaction in reutilization of deoxyguanosine for dGTP biosynthesis | ADP + dGMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
3 days old | - |
Purification (Comment) | Organism |
---|---|
pH 5.7, streptomycin sulfate, ammonium sulfate | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin | neonatal skin tissue | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0007 | - |
- |
Mus musculus |
Storage Stability | Organism |
---|---|
-20°C, ammonium sulfate precipitate in 100 mM M Tris-acetate buffer, pH 8, 0.025 M 2-mercaptoethanol, at least 4 months | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxyguanosine | no activity with deoxycytidine | Mus musculus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | no activity with dATP or GTP | Mus musculus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | no activity with deoxythymidine, uridine and cytosine | Mus musculus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | no activity with dGTP | Mus musculus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | no activity with adenosine | Mus musculus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | ATP can be replaced by dTTP, CTP, dCTP and UTP | Mus musculus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | 84%, 64%, 35% and 20% of activity with ATP with dTTP, CTP, dCTP and UTP, respectively | Mus musculus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | first reaction in reutilization of deoxyguanosine for dGTP biosynthesis | Mus musculus | ADP + dGMP | - |
? | |
CTP + deoxyguanosine | 64% of activity with ATP | Mus musculus | CDP + dGMP | - |
? | |
dCTP + deoxyguanosine | 35% of activity with ATP | Mus musculus | dCDP + dGMP | - |
? | |
dTTP + deoxyguanosine | 84% of activity with ATP | Mus musculus | dTDP + dGMP | - |
? | |
UTP + deoxyguanosine | 20% of activity with ATP | Mus musculus | UDP + dGMP | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.2 | - |
substrate deoxyguanosine | Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 9 | approx. 20% of maximal activity at pH 4.5 and pH 6.5 respectively, approx. 10% of maximal activity at pH 9.0 | Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00007 | - |
dGTP | pH 5.2, 37°C, competitive vs. MgATP2-, at MgATP2- concentrations above 0.5 mM | Mus musculus | |
0.0007 | - |
dGDP | pH 5.2, 37°C, competitive vs. MgATP2-, at MgATP2- concentrations above 0.5 mM | Mus musculus | |
0.0019 | - |
dGTP | pH 5.2, 37°C, competitive vs. deoxyguanosine | Mus musculus | |
0.003 | - |
UDP | pH 5.2, 37°C, competitive vs. MgATP2-, at MgATP2- concentrations above 0.5 mM | Mus musculus | |
0.18 | - |
dGMP | pH 5.2, 37°C, competitive vs. deoxyguanosine | Mus musculus |