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Literature summary for 2.7.1.11 extracted from

  • Lee, J.; Shao, F.; Ling, J.; Lu, S.; Liu, R.; Du, L.; Chung, J.; Koh, S.; Leem, S.; Shao, J.; Xing, D.; An, Z.; Lu, Z.
    Phosphofructokinase 1 platelet isoform promotes beta-catenin transactivation for tumor development (2020), Front. Oncol., 10, 211 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-fructose 6-phosphate Homo sapiens the enzyme catalyzes a rate-limiting reaction in glycolysis ADP + D-fructose 1,6-bisphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q01813
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose 6-phosphate
-
 Homo sapiens ADP + D-fructose 1,6-bisphosphate
-
 ?
ATP + D-fructose 6-phosphate the enzyme catalyzes a rate-limiting reaction in glycolysis Homo sapiens ADP + D-fructose 1,6-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PFKP phosphofructokinase 1 platelet isoform Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme catalyzes a rate-limiting reaction in glycolysis. The enzyme (PFKP) promotes EGFR activation-induced nuclear translocation and activation of beta-catenin in a PFKP Y64 phosphorylation-dependent manner, thereby enhancing the expression of beta-catenin downstream genes CCND1 and MYC. Thus, PFKP Y64 phosphorylation enhances tumor cell migration, invasion, proliferation, and brain tumor growth Homo sapiens