Literature summary for 2.7.1.11 extracted from

Walker, L.R.; Simcock, D.C.; Pedley, K.C.; Simpson, H.V.; Brown, S.
The kinetics and regulation of phosphofructokinase from Teladorsagia circumcincta (2012), Exp. Parasitol., 130, 348-353.

Search for more literature for 2.7.1.11

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	D-glucose 1,6-bisphosphate and phosphoenolpyruvate have no effect on activity	Teladorsagia circumcincta

Inhibitors

Inhibitors	Comment	Organism	Structure
ATP	allosteric inhibition by high ATP concentrations. The inhibitory effects of high ATP concentration can be reversed by D-fructose 2,6-bisphosphate and AMP	Teladorsagia circumcincta
citrate	mild inhibitory effects, but only at concentrations exceeding 2 mM	Teladorsagia circumcincta
isocitrate	mild inhibitory effects, but only at concentrations exceeding 2 mM	Teladorsagia circumcincta
malate	mild inhibitory effects, but only at concentrations exceeding 2 mM	Teladorsagia circumcincta

Organism

Organism	UniProt	Comment	Textmining
Teladorsagia circumcincta	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adult	-	Teladorsagia circumcincta	-
larva	-	Teladorsagia circumcincta	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-fructose 6-phosphate	-	Teladorsagia circumcincta	ADP + D-fructose 1,6-bisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
hosphofructokinase-1	-	Teladorsagia circumcincta
PFK-1	-	Teladorsagia circumcincta

Expression

Organism	Comment	Expression
Teladorsagia circumcincta	enzyme activities are higher in the adult stage as compared to L3 larval stages	up

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Release 2023.1 (January 2023)