Literature summary for 2.7.1.11 extracted from

Mlakar, T.; Legisa, M.
citrate inhibition-resistant form of 6-phosphofructo-1-kinase from Aspergillus niger (2006), Appl. Environ. Microbiol., 72, 4515-4521.

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Activating Compound

Activating Compound	Comment	Organism	Structure
AMP	activates 85000 Da native enzyme form and the 49000 Da shorter fragment	Aspergillus niger
NH4+	activates	Aspergillus niger

Inhibitors

Inhibitors	Comment	Organism	Structure
citrate	the native 85000 Da enzyme is moderately inhibited by citrate, the 49000 Da shorter fragment of PFK1 proves to be completely resistant to inhibition by citrate	Aspergillus niger

Organism

Organism	UniProt	Comment	Textmining
Aspergillus niger	P78985	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the 49000 Da fragment is formed from the 85000 Da native enzyme by posttranslational modification. The native 85000 Da enzyme is moderately inhibited by citrate, the 49000 Da shorter fragment of PFK1 proves to be completely resistant to inhibition by citrate	Aspergillus niger

Synonyms

Synonyms	Comment	Organism
PFK1	-	Aspergillus niger

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.5	-	citrate	pH 7.8, in presence of 5 mM Mg2+, native enzyme form	Aspergillus niger

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Release 2023.1 (January 2023)