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Literature summary for 2.7.1.108 extracted from

  • Juchimiuk, M.; Pasikowska, M.; Zatorska, E.; Laudy, A.E.; Smole?ska-Sym, G.; Palamarczyk, G.
    Defect in dolichol-dependent glycosylation increases sensitivity of Saccharomyces cerevisiae towards anti-fungal drugs (2010), Yeast, 27, 637-645.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P20048
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General Information

General Information Comment Organism
physiological function a strain impaired in dolichol kinase function shows aberrant cell wall structure and composition. the strain is resistant to itraconazole, but sensitive to 5-fluorocytosine, amphotericin B, caspofungin. The minimal inhibitory concentration of caspofungin and amphotericin B is 2fold lower for the mutant than for the respective wild-type strain. The sensitivity of the mutant can be brought back to the wild-type level by a multicopy suppressor of the thermosensitive phenotype, the RER2 gene, encoding cis-prenyltransferase involved in dolichol biosynthesis Saccharomyces cerevisiae