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Literature summary for 2.7.1.107 extracted from

  • Murakami, E.; Shionoya, T.; Komenoi, S.; Suzuki, Y.; Sakane, F.
    Cloning and characterization of novel testis-specific diacylglycerol kinase eta splice variants 3 and 4 (2016), PLoS ONE, 11, e0162997 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.107

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm when osmotically shocked with 0.5 M sorbitol, isoform DGKeta4 is distributed in punctate vesicles in the cytoplasm Homo sapiens 5737
-
plasma membrane when osmotically shocked with 0.5 M sorbitol, isoform DGKeta3 is partly translocated to the plasma membrane and co-localizes with the actin cytoskeleton Homo sapiens 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol Homo sapiens
-
 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86XP1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NEC-8 cell
-
 Homo sapiens
-
spermatid expressed in round spermatids Homo sapiens
-
spermatocyte expressed in the secondary spermatocytes Homo sapiens
-
testis isoform DGKeta is testis-specific Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol
-
 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
ATP + 1,2-dioleoyl-sn-glycerol
-
 Homo sapiens ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
 ?
additional information enzymatically active splice variant DGKeta3 lacks exon 26 encoding 31 amino acid residues. Splice variant DGKeta4 lacks the C-terminal half of variant DGKeta3 and has no enzymatic activity Homo sapiens ?
-
-

Subunits

Subunits Comment Organism
? x * 124000, isoform DGKeta3, calculated from amino acid sequence Homo sapiens
? x * 126000, isoform DGKeta3, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
DGKeta3 splice variant Homo sapiens
DGKeta4 splice variant Homo sapiens
diacylglycerol kinase eta isoform Homo sapiens

General Information

General Information Comment Organism
physiological function isoform DGKeta3 plays specialized roles in spermatogenesis Homo sapiens