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Literature summary for 2.7.1.107 extracted from

  • Takeuchi, M.; Sakiyama, S.; Usuki, T.; Sakai, H.; Sakane, F.
    Diacylglycerol kinase delta1 transiently translocates to the plasma membrane in response to high glucose (2012), Biochim. Biophys. Acta, 1823, 2210-2216.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm isoform diacylglycerol kinase delta-1, but not a splice variant isoform diacylglycerol kinase delta-2 or the other type II isoform diacylglycerol kinase ny-1/2, translocates from the cytoplasm to the plasma membrane in HEK-293 and mouse myoblast C2C12 cells within 5 min in response to high glucose levels. The translocation is inhibited by phosphatidylinositol 3-kinase inhibitors, LY294002 and GDC-0941. The PH and C1 domains are responsible for the plasma membrane translocation and the sterile alpha-motif domain negatively regulates the translocation Homo sapiens 5737
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plasma membrane isoform diacylglycerol kinase delta-1, but not a splice variant isoform diacylglycerol kinase delta-2 or the other type II isoform diacylglycerol kinase ny-1/2, translocates from the cytoplasm to the plasma membrane in HEK-293 and mouse myoblast C2C12 cells within 5 min in response to high glucose levels. The translocation is inhibited by phosphatidylinositol 3-kinase inhibitors, LY294002 and GDC-0941. The PH and C1 domains are responsible for the plasma membrane translocation and the sterile alpha-motif domain negatively regulates the translocation Homo sapiens 5886
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q16760 isoform diacylglycerol kinase delta
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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Homo sapiens
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