Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | localized in the narrow cytoplasmic space between smooth endoplasmic reticulum and plasma membrane | Rattus norvegicus | 5737 | - |
plasma membrane | - |
Rattus norvegicus | 5886 | - |
smooth endoplasmic reticulum | - |
Rattus norvegicus | 5790 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
90000 | - |
isoform DGKbeta, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P49621 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | moderate labeling in the hippocampus | Rattus norvegicus | - |
medium spiny neuron | DGKbeta is expressed in medium spiny neurons constituting the striatonigral and striatopallidal pathways, whereas striatal interneurons are below the detection threshold | Rattus norvegicus | - |
neocortex | weak labeling in the neocortex | Rattus norvegicus | - |
olfactory bulb | weak labeling in the olfactory bulb | Rattus norvegicus | - |
striatum | diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacylglycerol | - |
Rattus norvegicus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGKbeta | - |
Rattus norvegicus |
diacylglycerol kinase beta | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform DGKbeta is provided to perisynaptic sites of medium spiny neurons so that it can effectively produce 1,2-diacyl-sn-glycerol 3-phosphate upon activation of Gq protein-coupled receptors and modulate the cellular state of striatal output neurons | Rattus norvegicus |