Literature summary for 2.7.1.107 extracted from

Niizeki, T.; Takeishi, Y.; Kitahara, T.; Arimoto, T.; Koyama, Y.; Goto, K.; Mende, U.; Kubota, I.
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice (2008), Circ. J., 72, 309-317.

Search for more literature for 2.7.1.107

Application

Application	Comment	Organism
medicine	diacylglycerol kinase zeta blocks cardiac dysfunction and progression to lethal heart failure by activated G-protein subunit alphaq protein without detectable adverse effects in the in-vivo heart	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of double transgenic mice with cardiac-specific overexpression of both diacylglycerol kinase zeta and G-protein subunit alphaq. Diacylglycerol kinase zeta prevents cardiac dysfunction, determined by dilatation of left ventricular dimensions, reduction of left ventricular fractional shortening, and marked increases in left ventricular end-diastolic pressure in G-protein subunit alphaq transgenic mice. Translocation of protein kinase C isoforms, phosphorylation activity of c-jun N-terminal kinase and p38 mitogen-activated protein kinase in G-protein subunit alphaq transgenic mice are attenuated by diacylglycerol kinase zeta?. Diacylglycerol kinase zeta improves the survival rate of G-protein subunit alphaq transgenic mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q80UP3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)