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Literature summary for 2.7.1.107 extracted from

  • Chibalin, A.V.; Leng, Y.; Vieira, E.; Krook, A.; Bjoernholm, M.; Long, Y.C.; Kotova, O.; Zhong, Z.; Sakane, F.; Steiler, T.; Nylen, C.; Wang, J.; Laakso, M.; Topham, M.K.; Gilbert, M.; Wallberg-Henriksson, H.; Zierath, J.R.
    Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance (2008), Cell, 132, 375-386.
    View publication on PubMed

Application

Application Comment Organism
medicine diacylglycerol kinase delta haploinsufficiency increases diacylglycerol content, reduces peripheral insulin sensitivity, insulin signaling, and glucose transport, and leads to age-dependent obesity. Metabolic flexibility is impaired Mus musculus
medicine patients with type 2 diabetes mellitus display reduced diacylglycerol kinase delta expression and activity in skeletal muscle Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of heterozygous diacylglycerol kinase delta whole-body knockout mice. Diacylglycerol kinase delta haploinsufficiency increases diacylglycerol content, reduces peripheral insulin sensitivity, insulin signaling, and glucose transport, and leads to age-dependent obesity. Metabolic flexibility is impaired Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
R59022 decrease in total diacylglycerol kinase activity and increases in diacylglycerol levels upon incubation of skeletal muscle, with parallel increase in protein kinase C activity and isoform-specific phosphorylation of protein kinase Cdelta. Diacylglycerol kinase inhibition also reduces insulin-stimulated glucose transport Rattus norvegicus
R59949 decrease in total diacylglycerol kinase activity and increases in diacylglycerol levels upon incubation of skeletal muscle, with parallel increase in protein kinase C activity and isoform-specific phosphorylation of protein kinase Cdelta. Diacylglycerol kinase inhibition also reduces insulin-stimulated glucose transport Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane mainly associated with internal membranes Rattus norvegicus 16020
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q16760
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Mus musculus
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Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle epitrochlearis muscle Mus musculus
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skeletal muscle epitrochlearis muscle Rattus norvegicus
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skeletal muscle patients with type 2 diabetes mellitus display reduced diacylglycerol kinase delta expression and activity in skeletal muscle Homo sapiens
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