Literature summary for 2.7.1.107 extracted from

Niizeki, T.; Takeishi, Y.; Arimoto, T.; Takahashi, H.; Shishido, T.; Koyama, Y.; Goto, K.; Walsh, R.A.; Kubota, I.
Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction (2007), Am. J. Physiol., 292, H1105-H1112.

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Application

Application	Comment	Organism
medicine	transgenic mice with cardiac-specific overexpression of diacylglycerol kinase zeta. Left ventricular chamber dilatation, reduction of left ventricular systolic function and increases in left ventricular weight and lung weight at 4 weeks after myocardial infarction are attenuated in transgenic mice compared with wild-type mice. In the noninfarct area, fibrosis fraction and upregulation of profibrotic genes, such as transforming growth factor-1, collagen type I, and collagen type III, are blocked in transgenic mice. Survival rate at 4 weeks after myocardial infarction is higher in transgenic mice than in wild-type	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	transgenic mice with cardiac-specific overexpression of diacylglycerol kinase zeta. Left ventricular chamber dilatation, reduction of left ventricular systolic function and increases in left ventricular weight and lung weight at 4 weeks after myocardial infarction are attenuated in transgenic mice compared with wild-type mice. In the noninfarct area, fibrosis fraction and upregulation of profibrotic genes, such as transforming growth factor-1, collagen type I, and collagen type III, are blocked in transgenic mice. Survival rate at 4 weeks after myocardial infarction is higher in transgenic mice than in wild-type	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q80UP3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Mus musculus	-

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Release 2023.1 (January 2023)