Cloned (Comment) | Organism |
---|---|
high kinase activity is shown in COS cells transfected with either one of the three cDNAs for DGK-I, DGK-II or DGK-III | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasmic vesicle | DGK-II | Rattus norvegicus | 31410 | - |
cytoplasmic vesicle | DGK-III | Rattus norvegicus | 31410 | - |
particle-bound | activity of DGK-I is recovered dominantly in the soluble fraction, that for DGK-II in the particulate fraction and that for DGK-III in soluble and particulate fraction | Rattus norvegicus | - |
- |
soluble | activity of DGK-I is recovered dominantly in the soluble fraction, that for DGK-II in the particulate fraction and that for DGK-III in soluble and particulate fraction | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacyl-sn-glycerol | Rattus norvegicus | the enzyme is involved in resynthesis of phosphatidylinositol by converting a second messenger diacylglycerol to phosphatidic acid | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
DGK-I, DGK-II and DGK-III | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
caudate putamen | neuron, DGK-II | Rattus norvegicus | - |
cerebellar Purkinje cell | DGK-III | Rattus norvegicus | - |
neuron | of accumbens nucleus, caudate-putamen and olfactory tubercle, DGK-II | Rattus norvegicus | - |
nucleus accumbens | DGK-II | Rattus norvegicus | - |
olfactory tubercle | DGK-II | Rattus norvegicus | - |
oligodendrocyte | DGK-I | Rattus norvegicus | - |
spleen | DGK-I | Rattus norvegicus | - |
T-lymphocyte | DGK-I | Rattus norvegicus | - |
thymus | DGK-I | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacyl-sn-glycerol | the enzyme is involved in resynthesis of phosphatidylinositol by converting a second messenger diacylglycerol to phosphatidic acid | Rattus norvegicus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |