Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.105 extracted from

  • Loiseau, A.M.; Rider, M.H.; Hue, L.
    Purification and properties of 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase from rat hepatoma cells (1987), Biochem. Soc. Trans., 15, 384-385.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
citrate
-
Rattus norvegicus
additional information phosphorylation by cAMP-dependent protein kinase causes 80% decrease in activity of the liver cells but not of hepatoma cells; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Rattus norvegicus
phosphoenolpyruvate
-
Rattus norvegicus
sn-glycerol 3-phosphate 75% decrease in activity of liver enzyme but not hepatoma cells Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information comparison of Km of hepatoma cells and liver enzyme Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ MgATP2 Rattus norvegicus
phosphate activation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-fructose 6-phosphate Rattus norvegicus responsible for regulation of fructose 2,6-bisphosphate-concentration ADP + beta-D-fructose 2,6-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes 80% decrease in activity of the liver cells but not of hepatoma cells Rattus norvegicus
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell resembles muscle enzyme Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
?
ATP + beta-D-fructose 6-phosphate responsible for regulation of fructose 2,6-bisphosphate-concentration Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.025
-
citrate hepatoma cells Rattus norvegicus
0.035
-
citrate
-
Rattus norvegicus
0.12
-
phosphoenolpyruvate hepatoma cells Rattus norvegicus
0.2
-
phosphoenolpyruvate liver Rattus norvegicus
0.2
-
citrate liver Rattus norvegicus