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Literature summary for 2.7.1.105 extracted from
- Inhibition of growth by combined treatment with inhibitors of lactate dehydrogenase and either phenformin or inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (2016), Anticancer Res., 36, 1479-1488 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in colonic and bladder cancer cells, additive growth inhibitory effects are seen with phenformin and with an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3. The increased acidification of the culture medium and glucose uptake caused by phenformin is blocked by combined treatment with PFKFB3 inhibitors | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-(3-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one | - |
Homo sapiens |  |
| 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16875 | isoform PFKFB3, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, EC 2.7.1.105 and EC 3.1.3.46, respectively | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 5637 cell | - |
Homo sapiens | - |
| Caco-2 cell | - |
Homo sapiens | - |
| HCT-116 cell | - |
Homo sapiens | - |
| HT-1197 cell | - |
Homo sapiens | - |
| HT-1376 cell | - |
Homo sapiens | - |
| HT-29 cell | - |
Homo sapiens | - |
| RT-4 cell | - |
Homo sapiens | - |
| SW-780 cell | - |
Homo sapiens | - |
| T-24 cell | - |
Homo sapiens | - |
| TCC-SUP cell | - |
Homo sapiens | - |
| UM-UC-3 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PFKFB3 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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