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Literature summary for 2.7.1.105 extracted from

  • Ros, S.; Santos, C.R.; Moco, S.; Baenke, F.; Kelly, G.; Howell, M.; Zamboni, N.; Schulze, A.
    Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival (2012), Cancer Discov., 2, 328-343.
    View publication on PubMed

Application

Application Comment Organism
medicine bifunctional 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 mRNA expression is greater in metastatic prostate cancer compared with primary tumors Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16877 bifunctional 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
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Expression

Organism Comment Expression
Homo sapiens bifunctional 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 mRNA expression is greater in metastatic prostate cancer compared with primary tumors up

General Information

General Information Comment Organism
physiological function enzyme is required to balance glycolytic activity and antioxidant production to maintain cellular redox balance in prostate cancer cells. Depletion of the enzyme inhibits tumor growth in a xenograft model, indicating that it is required under physiologic nutrient levels. Enzyme mRNA expression is greater in metastatic prostate cancer compared with primary tumors Homo sapiens