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Literature summary for 2.7.1.105 extracted from

  • Harada, Y.; Tominaga, N.; Watanabe, M.; Shimokawa, R.; Ishiguro, M.; Sakakibara, R.
    Inhibition of fructose-6-phosphate,2-kinase by N-bromoacetylethanolamine phosphate in vitro and in vivo (1997), J. Biochem., 121, 724-730.
    View publication on PubMed
Search for more literature for 2.7.1.105

Activating Compound

Activating Compound Comment Organism Structure
glucose inhibition by N-bromoacetylethanolamine Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
using of recombinant testis enzyme Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-bromoacetylethanolamine repetitive administration affects inhibition of glycolysis and lipid metabolism, causing suppression of body weight gain Mus musculus
N-bromoacetylethanolamine specific active site-directed inactivator of enzyme, in vitro and in vivo Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-fructose 6-phosphate Rattus norvegicus enzyme plays an indirect yet key role in the regulation of glucose metabolism ADP + beta-D-fructose 2,6-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Mus musculus
a
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
 Mus musculus ADP + beta-D-fructose 2,6-bisphosphate
-
 r
ATP + beta-D-fructose 6-phosphate
-
 Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 r
ATP + beta-D-fructose 6-phosphate enzyme plays an indirect yet key role in the regulation of glucose metabolism Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Mus musculus ?
-
 ?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Rattus norvegicus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2
-
 N-bromoacetylethanolamine pH 7.5, 30°C, recombinant testis enzyme Rattus norvegicus
15
-
 N-bromoacetylethanolamine pH 7.5, 30°C, crude liver extracts Mus musculus