Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.105 extracted from

  • Lee, Y.H.; Li, Y.; Uyeda, K.; Hasemann, C.A.
    Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (2003), J. Biol. Chem., 278, 523-530.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
the crystal structure of liver enzyme: a head-to-head homodimer, depending on the liganding conditions each subunit contains an ATPgammaS, ADP or P molecule to the kinase domain, and two phosphates, regardless of the liganding conditions, bound to phosphatase domain, structure of enzyme very similar to that of the rat testis isoform Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphorylation site: Ser-32 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-fructose 6-phosphate Homo sapiens
-
ADP + beta-D-fructose 2,6-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16118
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation site: Ser-32 Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate random mechanism Homo sapiens
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
Homo sapiens ADP + beta-D-fructose 2,6-bisphosphate
-
?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Homo sapiens ?
-
?