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Literature summary for 2.7.1.105 extracted from

  • Rider, M.H.
    Regulation of fructose-2,6-bisphosphate synthesis and breakdown in heart and skeletal muscle (1987), Biochem. Soc. Trans., 15, 988-991.
    View publication on PubMed
Search for more literature for 2.7.1.105

Inhibitors

Inhibitors Comment Organism Structure
citrate
-
 Bos taurus
citrate skeletal muscle enzyme is more sensitive than liver enzyme Columba sp.
citrate skeletal muscle enzyme is more sensitive than liver enzyme Rattus norvegicus
additional information no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme Bos taurus
additional information no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Columba sp.
additional information no inhibition by protein kinase C; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme Rattus norvegicus
phosphoenolpyruvate
-
 Bos taurus
phosphoenolpyruvate
-
 Rattus norvegicus
sn-glycerol 3-phosphate heart enzyme is less sensitive than liver Bos taurus
sn-glycerol 3-phosphate heart enzyme is less sensitive than liver; liver enzyme Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus
Mg2+
-
 Bos taurus
Mg2+
-
 Columba sp.
phosphate
-
 Bos taurus
phosphate
-
 Columba sp.
phosphate liver enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-fructose 6-phosphate Rattus norvegicus responsible for regulation of fructose 2,6-bisphosphate-concentration ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
ATP + beta-D-fructose 6-phosphate Bos taurus responsible for regulation of fructose 2,6-bisphosphate-concentration ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
ATP + beta-D-fructose 6-phosphate Columba sp. responsible for regulation of fructose 2,6-bisphosphate-concentration ADP + beta-D-fructose 2,6-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Columba sp.
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme Rattus norvegicus
phosphoprotein rat liver enzyme is inhibited by phosphorylation by cAMP-dependent protein kinase but not rat kidney, testis and skeletal muscle enzyme and bovine and rat heart enzyme Bos taurus
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Rattus norvegicus
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Bos taurus
phosphoprotein phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme Columba sp.

Reaction

Reaction Comment Organism Reaction ID
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Rattus norvegicus
a
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-
heart two isozymic forms Bos taurus
-
liver
-
 Rattus norvegicus
-
liver
-
 Bos taurus
-
skeletal muscle
-
 Rattus norvegicus
-
skeletal muscle
-
 Columba sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
 Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 r
ATP + beta-D-fructose 6-phosphate
-
 Bos taurus ADP + beta-D-fructose 2,6-bisphosphate
-
 r
ATP + beta-D-fructose 6-phosphate
-
 Columba sp. ADP + beta-D-fructose 2,6-bisphosphate
-
 r
ATP + beta-D-fructose 6-phosphate responsible for regulation of fructose 2,6-bisphosphate-concentration Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
ATP + beta-D-fructose 6-phosphate responsible for regulation of fructose 2,6-bisphosphate-concentration Bos taurus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
ATP + beta-D-fructose 6-phosphate responsible for regulation of fructose 2,6-bisphosphate-concentration Columba sp. ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Rattus norvegicus ?
-
 ?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Bos taurus ?
-
 ?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Columba sp. ?
-
 ?
additional information with discrete catalytic sites Rattus norvegicus ?
-
 ?
additional information with discrete catalytic sites Bos taurus ?
-
 ?
additional information with discrete catalytic sites Columba sp. ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
AMP
-
 Rattus norvegicus
AMP
-
 Bos taurus
AMP
-
 Columba sp.