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Literature summary for 2.7.1.1 extracted from

  • Yin, X.; Choudhury, M.; Kang, J.H.; Schaefbauer, K.J.; Jung, M.Y.; Andrianifahanana, M.; Hernandez, D.M.; Leof, E.B.
    Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-beta (2019), Sci. Signal., 12, eaax4067 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
lonidamine
-
Homo sapiens
lonidamine
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens P52789
-
-
Mus musculus O08528
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Mus musculus
-
fibroblast fibroblasts from patients with idiopathic pulmonary fibrosis exhibit an increased abundance of hexokinase 2 Homo sapiens
-

Synonyms

Synonyms Comment Organism
hexokinase 2
-
Homo sapiens
hexokinase 2
-
Mus musculus
HK2
-
Homo sapiens
HK2
-
Mus musculus

General Information

General Information Comment Organism
malfunction knockdown of hexokinase 2 or pharmacological inhibition of hexokinase 2 activity with Lonidamine decreased TGF-beta-stimulated fibrogenic processes, including profibrotic gene expression, cell migration, colony formation, and activation of the transcription factors YAP and TAZ, with no apparent effect on cellular viability Homo sapiens
metabolism hexokinase 2 couples glycolysis with the profibrotic actions of TGF-beta Homo sapiens
metabolism the enzyme is required for profibrotic TGF-beta signaling and YAP/TAZ activation Mus musculus