Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lonidamine | - |
Homo sapiens | |
lonidamine | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P52789 | - |
- |
Mus musculus | O08528 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
fibroblast | fibroblasts from patients with idiopathic pulmonary fibrosis exhibit an increased abundance of hexokinase 2 | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
hexokinase 2 | - |
Homo sapiens |
hexokinase 2 | - |
Mus musculus |
HK2 | - |
Homo sapiens |
HK2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of hexokinase 2 or pharmacological inhibition of hexokinase 2 activity with Lonidamine decreased TGF-beta-stimulated fibrogenic processes, including profibrotic gene expression, cell migration, colony formation, and activation of the transcription factors YAP and TAZ, with no apparent effect on cellular viability | Homo sapiens |
metabolism | hexokinase 2 couples glycolysis with the profibrotic actions of TGF-beta | Homo sapiens |
metabolism | the enzyme is required for profibrotic TGF-beta signaling and YAP/TAZ activation | Mus musculus |