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Literature summary for 2.7.1.1 extracted from

  • Bao, F.; Yang, K.; Wu, C.; Gao, S.; Wang, P.; Chen, L.; Li, H.
    New natural inhibitors of hexokinase 2 (HK2) Steroids from Ganoderma sinense (2018), Fitoterapia, 125, 123-129 .
    View publication on PubMed
Search for more literature for 2.7.1.1

Inhibitors

Inhibitors Comment Organism Structure
(22E,24R)-6beta-methoxyergosta-7,9(11),22-triene-3beta,5alpha-diol steroid from Ganoderma sinense. Potential drug candidate targeting at hexokinase 2 for cancer therapy Homo sapiens
22E-6beta-methoxyergosta-7,22-diene-3beta,5alpha-diol
-
 Homo sapiens
Benserazide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P52789
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell the enzyme is expressed at high level in cancer cells compared with normal cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
hexokinase 2
-
 Homo sapiens
HK2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00206
-
 pH and temperature not specified in the publication Homo sapiens (22E,24R)-6beta-methoxyergosta-7,9(11),22-triene-3beta,5alpha-diol
0.00552
-
 pH and temperature not specified in the publication Homo sapiens Benserazide
0.01452
-
 pH and temperature not specified in the publication Homo sapiens 22E-6beta-methoxyergosta-7,22-diene-3beta,5alpha-diol

General Information

General Information Comment Organism
metabolism rate-limiting enzyme in the first step of glycolysis pathway Homo sapiens