Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,5-dihydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
2-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
3-(methanesulfonyl)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
3-Bromopyruvate | - |
Homo sapiens | |
3-chloro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
3-methoxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
4-(2-hydroxyethoxy)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
4-(methanesulfonyl)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
4-butyl-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
4-chloro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
4-fluoro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
4-methoxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
4-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
5-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-2,3-dihydro-1H-indole-2-carbohydrazide | - |
Homo sapiens | |
6-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide | - |
Homo sapiens | |
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide | - |
Homo sapiens | |
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | - |
Homo sapiens | |
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-3-carbohydrazide | - |
Homo sapiens | |
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-4-carbohydrazide | - |
Homo sapiens | |
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]quinoline-2-carbohydrazide | - |
Homo sapiens | |
N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]thiophene-2-carbohydrazide | - |
Homo sapiens | |
N-(4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinecarbonyl]phenyl)cyclopropanecarboxamide | - |
Homo sapiens | |
ZINC03232404 | - |
Homo sapiens | |
ZINC03233449 | - |
Homo sapiens | |
ZINC39948337 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P52789 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SW-1990 cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
hexokinase 2 | - |
Homo sapiens |
HK2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00053 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 4-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00069 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]quinoline-2-carbohydrazide | |
0.0007 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00074 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide | |
0.00098 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 4-chloro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00102 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 2,5-dihydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00108 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00108 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 3-chloro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00115 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 4-butyl-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00117 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00126 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 6-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide | |
0.00151 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 4-(2-hydroxyethoxy)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00172 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-3-carbohydrazide | |
0.00202 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | N-(4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinecarbonyl]phenyl)cyclopropanecarboxamide | |
0.00207 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 2-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.0023 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 5-hydroxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-2,3-dihydro-1H-indole-2-carbohydrazide | |
0.00332 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 4-(methanesulfonyl)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00419 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 3-(methanesulfonyl)-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.0048 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]thiophene-2-carbohydrazide | |
0.00516 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 4-fluoro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00521 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 4-methoxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00589 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 3-methoxy-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzohydrazide | |
0.00643 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]pyridine-4-carbohydrazide | |
0.00817 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | ZINC03232404 | |
0.00939 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | ZINC03233449 | |
0.0101 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | ZINC39948337 | |
0.026 | - |
pH 8.0, temperature not specified in the publication | Homo sapiens | 3-Bromopyruvate |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme is a promising target for cancer therapy | Homo sapiens |