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Literature summary for 2.7.1.1 extracted from
- First evidence of changes in enzyme kinetics and stability of glucokinase affected by somatic cancer-associated variations (2019), Biochim. Biophys. Acta Proteins Proteom., 1867, 213-218 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GCK | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | glucokinase contributes to the reprogramming of energy metabolism in cancer cells. Activating glucokinase variations substantially increase affinity of the enzyme to glucose, disrupt the otherwise characteristic sigmoidal response to glucose and/or prolong the enzyme half-life. This, combined, facilitates glucose phosphorylation, thus supporting glycolysis and associated pathways | Homo sapiens |
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Release 2023.1 (January 2023)
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