Literature summary for 2.7.1.1 extracted from

Casey, A.K.; Miller, B.G.
Kinetic Basis of carbohydrate-mediated inhibition of human glucokinase by the glucokinase regulatory protein (2016), Biochemistry, 55, 2899-2902 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
glucokinase regulatory protein	competitive inhibitor of glucokinase. Binding of glucokinase regulatory protein (GKRP) to glucokinase (GCK) involves two steps, formation of an initial encounter complex followed by conformational equilibration between two GKRP-GCK states. Fructose 6-phosphate, an enhancer of GKRP action, promotes formation of the initial encounter complex via a 2.6fold increase in k(on) and stabilizes the complex through a 60fold decrease in k(of)	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
GCK	-	Homo sapiens

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Release 2023.1 (January 2023)