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Literature summary for 2.7.1.1 extracted from

  • Wolf, A.; Agnihotri, S.; Micallef, J.; Mukherjee, J.; Sabha, N.; Cairns, R.; Hawkins, C.; Guha, A.
    Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme (2011), J. Exp. Med., 208, 313-326.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Homo sapiens
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glioblastoma cell human glioblastoma multiforme shows increased HK2 expression, correlating with poor overall survival Homo sapiens
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Synonyms

Synonyms Comment Organism
hexokinase 2
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 Homo sapiens
HK2
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in contrast to normal brain and low-grade gliomas, which express predominantly HK1, human glioblastoma multiforme show show increased HK2 expression up

General Information

General Information Comment Organism
malfunction depletion of HK2 in GBM cells restores oxidative glucose metabolism and increases sensitivity to cell death inducers such as radiation and temozolomide. Intracranial xenografts of HK2-depleted GBM cells shows decreased proliferation and angiogenesis, but increased invasion, as well as diminished expression of hypoxia inducible factor 1alpha and vascular endothelial growth factor Homo sapiens