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Literature summary for 2.7.1.1 extracted from

  • Bhaskar, P.T.; Nogueira, V.; Patra, K.C.; Jeon, S.M.; Park, Y.; Robey, R.B.; Hay, N.
    mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition (2009), Mol. Cell. Biol., 29, 5136-5147.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.1

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose
-
 Mus musculus ADP + D-glucose 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
hexokinase II
-
 Mus musculus
HKII
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus serum deprivation markedly increases hexokinase II abundance in tuberous sclerosis complex 2-deficient cells up

General Information

General Information Comment Organism
malfunction knockdown of hexokinase II increases the apoptotic susceptibility of tuberous sclerosis complex 2-deficient cells to serum deprivation Mus musculus