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Literature summary for 2.7.1.1 extracted from

  • Iynedjian, P.B.
    Molecular physiology of mammalian glucokinase (2009), Cell. Mol. Life Sci., 66, 27-42.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.1

Activating Compound

Activating Compound Comment Organism Structure
bad peptide
-
 Rattus norvegicus
glucokinase-associated phosphatase
-
 Rattus norvegicus
additional information not affected by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Rattus norvegicus
pentaubiquitin
-
 Rattus norvegicus
propionyl-CoA carboxylase beta-subunit
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
glucokinase regulatory protein binding of fructose 6-phosphate to glucokinase regulatory protein favors the glucokinase regulatory protein-glucokinas interaction with a negative effect on enzyme activity, while binding of fructose-1-phosphate weakens the glucokinase regulatory protein-glucokinase interaction and releases active glucokinase, the reversible association of glucokinase with glucokinase regulatory protein does more than simply regulate the catalytic activity of glucokinase, it also appears to underlie the intracellular trafficking of glucokinase between cytoplasm and nucleus Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm glucose levels higher 5 mM or fructose addition to the medium causes a rapid translocation of glucokinase to a predominant cytoplasmic localization Rattus norvegicus 5737
-
nucleus glucokinase is mainly localized to the nuclei at glucose concentrations around 5 mM Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose
-
 Rattus norvegicus ADP + D-glucose 6-phosphate
-
 ?
hexose + ATP
-
 Rattus norvegicus ADP + hexose 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
GCK
-
 Rattus norvegicus
glucokinase
-
 Rattus norvegicus
hexokinase D
-
 Rattus norvegicus
hexokinase IV
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus in the liver, expression of glucokinase is strictly dependent on the presence of insulin, insulin induction of glucokinase in hepatocytes is suppressed by the inhibitors of phosphoinositide 3-kinase, wortmannin, and LY294002 up