Literature summary for 2.7.1.1 extracted from

Ralph, E.C.; Thomson, J.; Almaden, J.; Sun, S.
Glucose modulation of glucokinase activation by small molecules (2008), Biochemistry, 47, 5028-5036.

Search for more literature for 2.7.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
(6-ethoxyquinazolin-4-yl)(1-methyl-1H-pyrazol-3-yl)amine	increases glucokinase activity at glucose concentrations up to approximately 20 mM	Homo sapiens
(6-ethoxyquinazolin-4-yl)pyridin-2-ylamine	increases glucokinase activity at glucose concentrations below approximately 7 mM	Homo sapiens
(6-isopropoxyquinazolin-4-yl)(1-methyl-1H-pyrazol-3-yl)amine	increases glucokinase activity at glucose concentrations up to approximately 20 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
nickel and FLAG affinity column chromatography and gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreatic beta cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-glucose	-	Homo sapiens	ADP + D-glucose 6-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
glucokinase	-	Homo sapiens
hexokinase D	-	Homo sapiens
hexokinase IV	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)