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Literature summary for 2.7.1.1 extracted from
- Isozymes of plant hexokinase: occurrence, properties and functions (2007), Phytochemistry, 68, 709-731.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | 0.1 mM, 60% inhibition | Capsicum chacoense |  |
| ADP | 1 mM, 50% inhibition; about 50% inhibition at 1 mM | Pisum sativum | |
| ADP | 0.1 mM, 60% inhibition | Solanum chacoense | |
| ADP | 5 mM, about 50% inhibition | Solanum lycopersicum | |
| ADP | hexokinase 1 | Solanum tuberosum | |
| ADP | - |
Triticum aestivum | |
| ADP | 1 mM, 45% inhibition, enzyme from kernel. Inhibits non-cytosolic enzyme from root. No inhibition of the cytosolic enzyme from root; inhibition of non-cytosolic enzyme, no inhibition of cytosolic enzyme | Zea mays | |
| D-glucose 6-phosphate | - |
Solanum lycopersicum | |
| D-glucose 6-phosphate | hexokinase 1 | Solanum tuberosum | |
| D-glucose 6-phosphate | weak inhibition of enzyme from kernel. No effect on the enzyme from root; weak inhibition of enzyme from kernel, no inhibition of cytosolic and non-cytosolic enzyme from root | Zea mays | |
| mannoheptulose | - |
Solanum lycopersicum | |
| mannoheptulose | inhibition of non-cytosolic enzyme and cytosolic enzyme | Zea mays | |
| additional information | no inhibition by D-glucose 6-phosphate and D-trehalose 6-phosphate | Capsicum chacoense | |
| additional information | D-glucose 6-phosphate has no effect on the enzyme from seed | Pisum sativum | |
| additional information | D-glucose 6-phosphate has no effect | Solanum chacoense | |
| additional information | D-glucose 6-phosphate has no effect; no inhibition of hexokinase 2: D-glucose 6-phosphate | Solanum tuberosum |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Zea mays | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | Q9FZG4 | - |
- |
| Capsicum chacoense | - |
recombinant | - |
| Pisum sativum | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Solanum chacoense | - |
- |
- |
| Solanum lycopersicum | - |
- |
- |
| Solanum tuberosum | - |
- |
- |
| Solanum tuberosum | O64390 | - |
- |
| Solanum tuberosum | Q9SQ76 | - |
- |
| Triticum aestivum | - |
- |
- |
| Zea mays | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| germ | - |
Triticum aestivum | - |
| germ | - |
Capsicum chacoense | - |
| kernel | - |
Zea mays | - |
| root | - |
Zea mays | - |
| seed | - |
Pisum sativum | - |
| tuber | - |
Solanum tuberosum | - |
| tuber | - |
Solanum chacoense | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-glucose | - |
Triticum aestivum | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Pisum sativum | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Zea mays | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Solanum tuberosum | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Capsicum chacoense | ADP + D-glucose 6-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hexokinase 1 | - |
Solanum tuberosum |
| hexokinase 2 | - |
Solanum tuberosum |
| HK1 | - |
Solanum tuberosum |
| HK2 | - |
Solanum tuberosum |
| ScHK2 | - |
Solanum chacoense |
| ScHK2 | - |
Capsicum chacoense |
| ScHK2 | - |
Arabidopsis thaliana |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
ADP | non-cytosolic hexokinase from root | Zea mays | |
| 0.03 | - |
ADP | root, non-cytosolic enzyme | Zea mays | |
| 0.04 | - |
ADP | - |
Solanum tuberosum | |
| 0.04 | - |
ADP | hexokinase 1 | Solanum tuberosum | |
| 0.11 | - |
ADP | - |
Solanum tuberosum | |
| 0.11 | - |
ADP | hexokinase 2 | Solanum tuberosum | |
| 0.5 | - |
mannoheptulose | non-cytoslic hexokinase from root | Zea mays | |
| 0.5 | - |
mannoheptulose | non-cytosolic enzyme | Zea mays | |
| 1 | - |
ADP | - |
Triticum aestivum | |
| 4 | - |
D-glucose 6-phosphate | pH 7, hexokinase 1 | Solanum tuberosum | |
| 20 | - |
mannoheptulose | cytosolic enzyme | Zea mays | |
| 20 | - |
mannoheptulose | cytosolic hexokinase from root | Zea mays | |
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