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Literature summary for 2.7.1.1 extracted from
- Purification and characterization of hexokinase from Leishmania mexicana (2007), Parasitol. Res., 100, 803-810.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Leishmania mexicana |  |
| D-fructose | - |
Leishmania mexicana | |
| D-glucose 6-phosphate | moderate sensitivity to inhibition. Inhibition is competitive with respect to both ATP and glucose | Leishmania mexicana | |
| diphosphate | - |
Leishmania mexicana | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.066 | - |
D-glucose | - |
Leishmania mexicana | |
| 0.142 | - |
D-fructose | - |
Leishmania mexicana | |
| 0.303 | - |
ATP | - |
Leishmania mexicana | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| glycosome | - |
Leishmania mexicana | 20015 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania mexicana | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Leishmania mexicana |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| amastigote | obtained from hamster lesion | Leishmania mexicana | - |
| promastigote | specific activity increases with the aging of promastigote culture (related to glucose consumption). The level of the hexokinase protein remains constant | Leishmania mexicana | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Leishmania mexicana |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose + ATP | - |
Leishmania mexicana | D-fructose 6-phosphate + ADP | - |
? | |
| D-glucose + ATP | - |
Leishmania mexicana | ADP + D-glucose 6-phosphate | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Leishmania mexicana |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 9 | - |
Leishmania mexicana |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.035 | - |
diphosphate | inhibition with respect to ATP | Leishmania mexicana | |
| 0.23 | - |
D-fructose | inhibition with respect to glucose | Leishmania mexicana | |
| 0.43 | - |
D-glucose 6-phosphate | inhibition with respect to glucose | Leishmania mexicana | |
| 0.7 | - |
D-glucose 6-phosphate | inhibition with respect to ATP | Leishmania mexicana | |
| 0.723 | - |
ADP | inhibition with respect to ATP | Leishmania mexicana | |
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