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Literature summary for 2.7.1.1 extracted from

  • Muzi, M.; Freeman, S.D.; Burrows, R.C.; Wiseman, R.W.; Link, J.M.; Krohn, K.A.; Graham, M.M.; Spence, A.M.
    Kinetic characterization of hexokinase isoenzymes from glioma cells: Implications for FDG imaging of human brain tumors (2001), Nucl. Med. Biol., 28, 107-116.
    View publication on PubMed

Application

Application Comment Organism
diagnostics increased proportion of hexokinase II is used as a marker for brain tumors Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.032 0.034 D-glucose HK I, at 25°C, pH 7.4 Bos taurus
0.039
-
D-glucose HK I, at 25°C, pH 7.4 Rattus norvegicus
0.055 0.062 2-fluoro-2-deoxy-D-glucose HK I, at 25°C, pH 7.4 Bos taurus
0.068 0.077 2-fluoro-2-deoxy-D-glucose HK I, at 25°C, pH 7.4 Rattus norvegicus
0.129 0.137 D-glucose HK II, at 25°C, pH 7.4 Rattus norvegicus
0.152
-
2-deoxy-D-glucose HKI, at 25°C, pH 7.4 Bos taurus
0.166 0.174 2-fluoro-2-deoxy-D-glucose HK II, at 25°C, pH 7.4 Rattus norvegicus
0.18
-
2-deoxy-D-glucose HKI, at 25°C, pH 7.4 Rattus norvegicus
0.613
-
2-deoxy-D-glucose HKII, at 25°C, pH 7.4 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose + ATP Homo sapiens glucose metabolism D-glucose 6-phosphate + ADP
-
?
D-glucose + ATP Rattus norvegicus glucose metabolism D-glucose 6-phosphate + ADP
-
?
D-glucose + ATP Bos taurus glucose metabolism D-glucose 6-phosphate + ADP
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
hexokinase I
-
Homo sapiens
-
-
-
Rattus norvegicus
-
hexokinase type II
-
Rattus norvegicus
-
hexokinase type I
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte hexokinase I: predominant in normal brain, hexokinase II: increased in brain tumors, ethylnitrosourea-induced 36B-10 astrocytic F-344 rat brain tumor cell line Rattus norvegicus
-
glioma cell hexokinase I, predominant in normal brain Rattus norvegicus
-
glioma cell hexokinase I, predominant in normal brain Bos taurus
-
glioma cell hexokinase II, increased in brain tumors, ethylnitrosourea-induced 36B-10 astrocytic F-344 rat brain tumor cell line Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-fluoro-2-deoxy-D-glucose + ATP
-
Rattus norvegicus 2-fluoro-2-deoxy-D-glucose 6-phosphate + ADP
-
?
2-fluoro-2-deoxy-D-glucose + ATP
-
Bos taurus 2-fluoro-2-deoxy-D-glucose 6-phosphate + ADP
-
?
ATP + 2-deoxy-D-glucose
-
Homo sapiens ADP + 2-deoxy-D-glucose 6-phosphate
-
?
ATP + 2-deoxy-D-glucose
-
Rattus norvegicus ADP + 2-deoxy-D-glucose 6-phosphate
-
?
ATP + 2-deoxy-D-glucose
-
Bos taurus ADP + 2-deoxy-D-glucose 6-phosphate
-
?
D-glucose + ATP
-
Homo sapiens ADP + D-glucose 6-phosphate
-
?
D-glucose + ATP
-
Rattus norvegicus ADP + D-glucose 6-phosphate
-
?
D-glucose + ATP
-
Bos taurus ADP + D-glucose 6-phosphate
-
?
D-glucose + ATP glucose metabolism Homo sapiens D-glucose 6-phosphate + ADP
-
?
D-glucose + ATP glucose metabolism Rattus norvegicus D-glucose 6-phosphate + ADP
-
?
D-glucose + ATP glucose metabolism Bos taurus D-glucose 6-phosphate + ADP
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens
25
-
assay at Rattus norvegicus
25
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus
7.4
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
ATP
-
Bos taurus