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Literature summary for 2.7.1.1 extracted from

  • Magnani, M.; Stocchi, V.; Serafini, N.; Piatti, E.; Dacha, M.; Fornaini, G.
    Pig red blood cell hexokinase: Regulatory characteristics and possible physiological role (1983), Arch. Biochem. Biophys., 226, 377-387.
    View publication on PubMed
Search for more literature for 2.7.1.1

Inhibitors

Inhibitors Comment Organism Structure
2,3-diphosphoglycerate hexokinase III Sus scrofa
2-phosphoglycerate hexokinase III Sus scrofa
3-phosphoglycerate hexokinase III Sus scrofa
ADP hexokinase III Sus scrofa
ATP ATP4-; hexokinase III; uncomplexed, competitive to MgATP2-, erythrocyte enzyme Sus scrofa
D-fructose 1,6-diphosphate hexokinase III Sus scrofa
D-fructose 6-phosphate hexokinase III Sus scrofa
D-glucose higher than 0.4 mM; inhibits hexokinase III Sus scrofa
D-glucose 1,6-diphosphate hexokinase III Sus scrofa
D-glucose 6-phosphate hexokinase III, poor inhibitor, not relieved by phosphate Sus scrofa
dihydroxyacetonephosphate hexokinase III Sus scrofa
Mg2+ competitive to MgATP2-; uncomplexed Sus scrofa
additional information not inhibited by glyceraldehyde 3-phosphate, pyruvate, lactate Sus scrofa
phosphate hexokinase III Sus scrofa
phosphoenolpyruvate hexokinase III Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
 ATP hexokinase III, at 30°C, pH 8.1 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose + ATP Sus scrofa the presence of type III hexokinase enables the adult pig erythrocytes to metabolize low but appreciable amounts of glucose D-glucose 6-phosphate + ADP
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
 2 enzyme forms: hexokinase type II and type III
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte hexokinase types II and III, hexokinase III is the predominant form in adult pig erythrocytes, hexokinase II in newborn pig erythrocytes Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose + ATP
-
 Sus scrofa ADP + D-glucose 6-phosphate
-
 ?
D-glucose + ATP the presence of type III hexokinase enables the adult pig erythrocytes to metabolize low but appreciable amounts of glucose Sus scrofa D-glucose 6-phosphate + ADP
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.04
-
 D-glucose 1,6-diphosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
0.12
-
 D-glucose 6-phosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
0.5
-
 ADP hexokinase III, at 30°C, pH 7.2 Sus scrofa
0.5
-
 D-fructose 6-phosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
0.5
-
 ATP uncomplexed ATP4-, hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.5
-
 D-fructose 1,6-diphosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
2.5
-
 dihydroxyacetonephosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
5
-
 2,3-diphosphoglycerate hexokinase III, at 30°C, pH 7.2 Sus scrofa
7.8
-
 phosphate hexokinase III, at 30°C, pH 7.2 Sus scrofa
8
-
 phosphoenolpyruvate hexokinase III, at 30°C, pH 7.2 Sus scrofa
12
-
 3-phosphoglycerate hexokinase III, at 30°C, pH 7.2 Sus scrofa
13
-
 2-phosphoglycerate hexokinase III, at 30°C, pH 7.2 Sus scrofa
30
-
 Mg2+ uncomplexed, hexokinase III, at 30°C, pH 7.2 Sus scrofa