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Literature summary for 2.7.1.1 extracted from

  • Liu, S.S.; Witkovsky, P.; Yang, C.Y.
    Retinal hexokinase: kinetic properties and the effect of cyclic 3,5-adenosine monophosphate (1983), J. Neurochem., 41, 1694-1701.
    View publication on PubMed
Search for more literature for 2.7.1.1

Inhibitors

Inhibitors Comment Organism Structure
D-glucose 6-phosphate marked inhibition of particulate hexokinase I activity Lithobates catesbeianus
GSSG product inhibition Lithobates catesbeianus
additional information not inhibited by 2-deoxy-D-glucose 6-phosphate Lithobates catesbeianus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
 D-glucose
-
 Lithobates catesbeianus
3.6
-
 2-deoxy-D-glucose
-
 Lithobates catesbeianus

Localization

Localization Comment Organism GeneOntology No. Textmining
particle-bound 73% of the activity in retinas is associated with the particulate fraction and 27% with the soluble fraction Lithobates catesbeianus
-
-
soluble 73% of the activity in retinas is associated with the particulate fraction and 27% with the soluble fraction Lithobates catesbeianus
-
-

Organism

Organism UniProt Comment Textmining
Lithobates catesbeianus
-
 bullfrog, hexokinase I
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
-
 Lithobates catesbeianus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-deoxy-D-glucose
-
 Lithobates catesbeianus ADP + 2-deoxy-D-glucose 6-phosphate
-
 ?
D-fructose + ATP
-
 Lithobates catesbeianus ADP + D-fructose 6-phosphate
-
 ?
D-glucose + ATP
-
 Lithobates catesbeianus ADP + D-glucose 6-phosphate
-
 ?
D-mannose + ATP
-
 Lithobates catesbeianus ADP + D-mannose 6-phosphate
-
 ?
additional information not: D-galactose Lithobates catesbeianus ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
AMP much less stimulation than by cAMP Lithobates catesbeianus
ATP
-
 Lithobates catesbeianus
cAMP stimulates, 0.2-0.8 mM: 2fold Lithobates catesbeianus