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Literature summary for 2.6.99.2 extracted from
- Structural basis for the function of pyridoxine 5'-phosphate synthase (2001), Structure, 9, 245-253.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| purified enzyme in complex with products pyridoxine 5'-phosphate and phosphate, the enzyme crystals are incubated with 5 mM product solution for 1 h, X-ray diffraction structure determination and analysis at 2.3 A resolution | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | Escherichia coli | - |
pyridoxine 5'-phosphate + phosphate + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P0A794 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O | reaction mechanism, Arg20 is involved in substrate binding, active site structure, structure-function relationship | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | - |
Escherichia coli | pyridoxine 5'-phosphate + phosphate + H2O | - |
? | |
| 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate | Arg20 is involved in substrate binding | Escherichia coli | pyridoxine 5'-phosphate + phosphate + H2O | product binding structure | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | the enzyme contains one abundant TIM barrel fold domain, intersubunit contacts are mediated by 3 additional helices, respective to the classical TIM barrel helices | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PdxJ | - |
Escherichia coli |
| PNP synthase | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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