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Literature summary for 2.6.99.2 extracted from

  • Garrido-Franco, M.
    Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond (2003), Biochim. Biophys. Acta, 1647, 92-97.
    View publication on PubMed

Application

Application Comment Organism
pharmacology the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate Salmonella enterica subsp. enterica serovar Typhimurium
pharmacology the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate Escherichia coli
pharmacology the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate Neisseria gonorrhoeae
pharmacology the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate Neisseria meningitidis
pharmacology the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate Yersinia pestis
pharmacology the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate Salmonella enterica subsp. enterica serovar Typhi
pharmacology the enzyme is a target for drug development in the treatment of human pathogens being capable, in contrast to the hosts, to synthesize pyridoxine 5'-phosphate Vibrio cholerae serotype O1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate Salmonella enterica subsp. enterica serovar Typhimurium involved in the de novo synthesis of vitamin B6 pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate Neisseria gonorrhoeae involved in the de novo synthesis of vitamin B6 pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate Neisseria meningitidis involved in the de novo synthesis of vitamin B6 pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate Yersinia pestis involved in the de novo synthesis of vitamin B6 pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate Salmonella enterica subsp. enterica serovar Typhi involved in the de novo synthesis of vitamin B6 pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate Vibrio cholerae serotype O1 involved in the de novo synthesis of vitamin B6 pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate Escherichia coli key enzyme in the group of pdx gene-encoded enzymes involved in the de novo synthesis of vitamin B6 pyridoxine 5'-phosphate + phosphate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Neisseria gonorrhoeae
-
-
-
Neisseria meningitidis
-
-
-
Salmonella enterica subsp. enterica serovar Typhi
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Vibrio cholerae serotype O1
-
-
-
Yersinia pestis
-
-
-

Reaction

Reaction Comment Organism Reaction ID
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O reaction mechanism, active site structure, substrate and product binding structures, structure-function relationship Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate
-
Neisseria gonorrhoeae pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate
-
Neisseria meningitidis pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate
-
Yersinia pestis pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate
-
Salmonella enterica subsp. enterica serovar Typhi pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate
-
Vibrio cholerae serotype O1 pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate involved in the de novo synthesis of vitamin B6 Salmonella enterica subsp. enterica serovar Typhimurium pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate involved in the de novo synthesis of vitamin B6 Neisseria gonorrhoeae pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate involved in the de novo synthesis of vitamin B6 Neisseria meningitidis pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate involved in the de novo synthesis of vitamin B6 Yersinia pestis pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate involved in the de novo synthesis of vitamin B6 Salmonella enterica subsp. enterica serovar Typhi pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate involved in the de novo synthesis of vitamin B6 Vibrio cholerae serotype O1 pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate key enzyme in the group of pdx gene-encoded enzymes involved in the de novo synthesis of vitamin B6 Escherichia coli pyridoxine 5'-phosphate + phosphate + H2O
-
?
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate multistep ring closure reaction, the phosphate group of the substrate is required for activity Escherichia coli pyridoxine 5'-phosphate + phosphate + H2O
-
?
additional information 1-deoxy-D-xylulose is no substrate Escherichia coli ?
-
?

Subunits

Subunits Comment Organism
More enzyme structure, the monomer comprises a single domain which folds as a (beta/alpha)8 barrel or TIM barrel, 3 extra helices complete the scaffold mediating the intersubunit contact Escherichia coli
octamer in solution, crystal structure Escherichia coli

Synonyms

Synonyms Comment Organism
PdxJ
-
Escherichia coli
PNP synthase
-
Salmonella enterica subsp. enterica serovar Typhimurium
PNP synthase
-
Escherichia coli
PNP synthase
-
Neisseria gonorrhoeae
PNP synthase
-
Neisseria meningitidis
PNP synthase
-
Yersinia pestis
PNP synthase
-
Salmonella enterica subsp. enterica serovar Typhi
PNP synthase
-
Vibrio cholerae serotype O1