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Literature summary for 2.6.1.99 extracted from

  • Stepanova, A.N.; Robertson-Hoyt, J.; Yun, J.; Benavente, L.M.; Xie, D.Y.; Dolezal, K.; Schlereth, A.; Juergens, G.; Alonso, J.M.
    TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development (2008), Cell, 133, 177-191.
    View publication on PubMed
Search for more literature for 2.6.1.99

Protein Variants

Protein Variants Comment Organism
K217A the TAA1 mutant shows a defect in pyridoxal 5'-phosphate binding Arabidopsis thaliana
additional information phenotypes of multiple mutant combinations, strong ethylene defects of the wei8 tar2 roots and the typical ethylene-triggered differential growth of apical hooks is also blocked in wei8 tar2, wei8 tar2 mutants have reduced levels of auxin Arabidopsis thaliana
P166S wei8-2 utant version of TAA1 Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + pyruvate Arabidopsis thaliana
-
 indole-3-pyruvate + L-alanine
-
 ?
L-tryptophan + pyruvate Arabidopsis thaliana Col-0
-
 indole-3-pyruvate + L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9S7N2 gene wei8
-
Arabidopsis thaliana Col-0 Q9S7N2 gene wei8
-

Source Tissue

Source Tissue Comment Organism Textmining
flower
-
 Arabidopsis thaliana
-
leaf
-
 Arabidopsis thaliana
-
root
-
 Arabidopsis thaliana
-
seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + pyruvate
-
 Arabidopsis thaliana indole-3-pyruvate + L-alanine
-
 ?
L-tryptophan + pyruvate
-
 Arabidopsis thaliana Col-0 indole-3-pyruvate + L-alanine
-
 ?

Synonyms

Synonyms Comment Organism
TAA1
-
 Arabidopsis thaliana
TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS1
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
evolution TAA1 encodes a member of a small family of aminotransferases with strong sequence similarity to C-S Lyases Arabidopsis thaliana
malfunction the ethylene defects of wei8 are dramatically enhanced in the wei8 tar2 double mutants that display a nearly complete lack of response to ACC in roots Arabidopsis thaliana
metabolism gene wei8 encodes a long-anticipated tryptophan aminotransferase, TAA1, in the essential indole-3-pyruvic acid branch of the auxin biosynthetic pathway, a link between local auxin production, tissue-specific ethylene effects, and organ development exists. TAA1 and TAR2 have overlapping roles in the ethylene response, overview Arabidopsis thaliana
physiological function gene wei8 encodes a long-anticipated tryptophan aminotransferase, TAA1, in the essential indole-3-pyruvic acid branch of the auxin biosynthetic pathway, a link between local auxin production, tissue-specific ethylene effects, and organ development exists. The IPA route of auxin production is key to generating robust auxin gradients in response to environmental and developmental cues. Proper gynoecium development requires TAA1 and TAR2 function Arabidopsis thaliana