Data extracted from this reference:
Inhibitors
2-fluorochorismate
irreversible, covalent modification of K274
Escherichia coli
Organism
Reaction
chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
omega-amino group of K274 adds to chorismate at C2, leading to elimination of the C4 hydroxyl in an SN2'' displacement reaction. After attack of ammonia to intermediate, another SN2'' displacement expels K274 and forms aminodeoxychorismate
Escherichia coli
Subunits
dimer
heterodimer of chorismate aminating subunit and glutamine amidotransferase subunit. Mass of glutamine amidotransferase subunit is 50969 Da, as determined by electrospray mass spectrometry
Escherichia coli
Ki Value [mM]
0.13
2-fluorochorismate
Escherichia coli
Inhibitors (protein specific)
2-fluorochorismate
irreversible, covalent modification of K274
Escherichia coli
Ki Value [mM] (protein specific)
0.13
2-fluorochorismate
Escherichia coli
Subunits (protein specific)
dimer
heterodimer of chorismate aminating subunit and glutamine amidotransferase subunit. Mass of glutamine amidotransferase subunit is 50969 Da, as determined by electrospray mass spectrometry
Escherichia coli
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684435
Keller
Action of atrop-abyssomicin C ...
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Angew. Chem. Int. Ed. Engl.
46
8284-8286
2007
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661938
Bulloch
Identification of 4-amino-4-de ...
Escherichia coli
J. Am. Chem. Soc.
126
9912-9913
2004
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Escherichia coli
Biochemistry
41
2198-2208
2002
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644250
Chang
p-Aminobenzoic acid and chlora ...
Streptomyces venezuelae, Streptomyces venezuelae ISP5230
Microbiology
147
2113-2126
2001
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644248
Rayl
Escherichia coli aminodeoxycho ...
Escherichia coli
Biochim. Biophys. Acta
1295
81-88
1996
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644230
Viswanathan
Kinetic characterization of 4- ...
Escherichia coli
J. Bacteriol.
177
5918-5923
1995
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644227
Ye
p-Aminobenzoate synthesis in E ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
87
9391-9395
1990
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