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Literature summary for 2.6.1.81 extracted from

  • Jann, A.; Stalon, V.; Wauven, C.V.; Leisinger, T.; Haas, D.
    N-Succinylated intermediates in an arginine catabolic pathway of Pseudomonas aeruginosa (1986), Proc. Natl. Acad. Sci. USA, 83, 4937-4941.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information arginine induces the enzymes of the entire pathway, while succinate and ammonium suppress them Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
aminooxoacetic acid leads to accumulation of succinyl-L-ornithine in vivo Pseudomonas aeruginosa
additional information arginine induces the enzymes of the entire pathway, while succinate and ammonium suppress them Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N2-succinyl-L-ornithine + 2-oxoglutarate Pseudomonas aeruginosa step in metabolic conversion of L-arginine into L-glutamate, pathway overview N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
?
N2-succinyl-L-ornithine + 2-oxoglutarate Pseudomonas aeruginosa PAO step in metabolic conversion of L-arginine into L-glutamate, pathway overview N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-
Pseudomonas aeruginosa PAO
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N2-succinyl-L-ornithine + 2-oxoglutarate
-
Pseudomonas aeruginosa N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
?
N2-succinyl-L-ornithine + 2-oxoglutarate step in metabolic conversion of L-arginine into L-glutamate, pathway overview Pseudomonas aeruginosa N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
?
N2-succinyl-L-ornithine + 2-oxoglutarate
-
Pseudomonas aeruginosa PAO N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
?
N2-succinyl-L-ornithine + 2-oxoglutarate step in metabolic conversion of L-arginine into L-glutamate, pathway overview Pseudomonas aeruginosa PAO N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Pseudomonas aeruginosa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Pseudomonas aeruginosa