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Literature summary for 2.6.1.7 extracted from

  • Rossi, F.; Valentina, C.; Garavaglia, S.; Sathyasaikumar, K.V.; Schwarcz, R.; Kojima, S.; Okuwaki, K.; Ono, S.; Kajii, Y.; Rizzi, M.
    Crystal structure-based selective targeting of the pyridoxal 5-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement (2010), J. Med. Chem., 53, 5684-5689.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
maltose-binding protein fusion protein expressed in Escherichia coli BL21(DE3) Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
PEG 3350 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid BFF-122 Homo sapiens
L-2-aminoadipate
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N5Z0
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxoglutarate
-
Homo sapiens kynurenic acid + L-glutamate + H2O
-
?

Synonyms

Synonyms Comment Organism
kynurenine aminotransferase II
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00091
-
0.0015 mM or the two enantiomers, pH 8.0, 37°C Homo sapiens (S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid