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Literature summary for 2.6.1.7 extracted from

  • Han, Q.; Cai, T.; Tagle, D.; Li, J.
    Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases (2010), BMC Biochem., 11, 0019.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
tagged protein (consisting of an intein and a chitin binding domain) expressed in Escherichia coli Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
aspartate
-
Mus musculus
cysteine
-
Mus musculus
glutamate
-
Mus musculus
glutamine
-
Mus musculus
histidine
-
Mus musculus
Indole-3-propionic acid
-
Mus musculus
leucine
-
Mus musculus
methionine
-
Mus musculus
phenylalanine
-
Mus musculus
tryptophan
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P05202
-
-
Mus musculus Q71RI9
-
-
Mus musculus Q8BTY1
-
-
Mus musculus Q9WVM8
-
-

Purification (Commentary)

Purification (Comment) Organism
chitin affinity chromatography, cleavage of tag domain, ion exchange chromatography (DEAE-Sepharose and Mono-Q), gel filtration Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-

Storage Stability

Storage Stability Organism
freezing and thawing do not alter the activity Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxoglutarate
-
Mus musculus kynurenic acid + L-glutamate + H2O
-
?
L-kynurenine + 2-oxoglutarate highest activity with aspartate and glutamate as substrate, but also active with other amino acids Mus musculus kynurenic acid + L-glutamate + H2O
-
?
L-kynurenine + glyoxylate 2-oxobutyrate is also a co-substrate Mus musculus kynurenic acid + glycine + H2O
-
?
L-kynurenine + glyoxylate alpha-ketobutyrate is also a co-substrate Mus musculus kynurenic acid + glycine + H2O
-
?

Synonyms

Synonyms Comment Organism
aminoadipate aminotransferase
-
Mus musculus
cysteine conjugate beta-lyase 1
-
Mus musculus
cysteine conjugate beta-lyase 2
-
Mus musculus
glutamic-oxaloacetic transaminase 2
-
Mus musculus
glutamine transaminase K
-
Mus musculus
kynurenine aminotransferase I
-
Mus musculus
kynurenine aminotransferase II
-
Mus musculus
kynurenine aminotransferase III
-
Mus musculus
kynurenine aminotransferase IV
-
Mus musculus
mitochondrial aspartate aminotransferase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
59
-
-
Mus musculus
60
-
-
Mus musculus
60 70
-
Mus musculus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
midpoint temperature of protein melting 64.8°C, calculated half life time value at 65°C 3.9 min Mus musculus
additional information
-
midpoint temperature of protein melting 65.9°C, calculated half life time value at 65°C 27.4 min Mus musculus
additional information
-
midpoint temperature of protein melting 66.5°C, calculated half life time value at 65°C 6.5 min Mus musculus
additional information
-
midpoint temperature of protein melting 68.8°C, calculated half life time value at 65°C 69.7 min Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
Mus musculus
8
-
-
Mus musculus
9
-
-
Mus musculus