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Literature summary for 2.6.1.7 extracted from

  • Amori, L.; Guidetti, P.; Pellicciari, R.; Kajii, Y.; Schwarcz, R.
    On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo (2009), J. Neurochem., 109, 316-325.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.7

Inhibitors

Inhibitors Comment Organism Structure
(S)-9-(4-aminopiperazine-1-yl)-8-fluoro-3-methyl-6-oxo-2,3,5,6-tetrahydro-4H-1-oxa-3a-azaphenalene-5-carboxylic acid BFF 122, KAT II activity is totally blocked at 0.01 mM, 43% inhibition of KAT II at 0.001 mM, 26% inhibition of KAT I at 1 mM Rattus norvegicus
additional information KAT is not inhibited by UPF 648 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxobutyrate
-
 Rattus norvegicus kynurenic acid + 2-aminobutanoate + H2O
-
 ?

Synonyms

Synonyms Comment Organism
KAT I
-
 Rattus norvegicus
KAT II
-
 Rattus norvegicus
kynurenine aminotransferase I
-
 Rattus norvegicus
kynurenine aminotransferase II
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus