Literature summary for 2.6.1.7 extracted from

Kwok, J.B.J.; Kapoor, R.; Gotoda, T.; Iwamoto, Y.; Iizuka, Y.; Yamada, N.; Isaacs, K.E.; Kushwaha, V.V.; Church, W.B.; Schofield, P.R.; Kapoor, V.
A Missense Mutation in Kynurenine Aminotransferase-1 in Spontaneously Hypertensive Rats (2002), J. Biol. Chem., 277, 35779-35782.

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Protein Variants

Protein Variants	Comment	Organism
E61G	40-60% of wild-type activity, Km for L-kynurenine and pyruvate is reduced, missense mutation found in spontaneously hypertensive rats	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.1	-	pyruvate	E61G mutant KAT I from brain	Rattus norvegicus
0.2	-	L-kynurenine	E61G mutant KAT I from brain	Rattus norvegicus
1.2	-	pyruvate	recombinant brain KAT I	Rattus norvegicus
1.4	-	L-kynurenine	recombinant brain KAT I	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q08415	brain KAT I	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-kynurenine + pyruvate	-	Rattus norvegicus	kynurenic acid + L-alanine + H2O	-	?

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Release 2023.1 (January 2023)