Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-alanine | - |
Escherichia coli | |
L-alanine | growing this microorganism in the presence of alanine represses the gene encoding transaminase C | Salmonella enterica subsp. enterica serovar Typhimurium | |
L-leucine | - |
Escherichia coli | |
L-leucine | growing this microorganism in the presence of leucine represses the gene encoding transaminase C | Salmonella enterica subsp. enterica serovar Typhimurium | |
L-valine | growing this microorganism in the presence of valine diminishes transaminase C activity but does not repress avtA | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + 3-methyl-2-oxobutanoate | Salmonella enterica subsp. enterica serovar Typhimurium | mutations in the gene encoding this enzyme are silent unless they are combined with mutations involved in isoleucine-valine biosynthesis | L-valine + pyruvate | - |
r | |
L-alanine + 3-methyl-2-oxobutanoate | Escherichia coli | mutations in the gene encoding this enzyme are silent unless they are combined with mutations involved in isoleucine-valine biosynthesis | L-valine + pyruvate | - |
r | |
L-alanine + 3-methyl-2-oxobutanoate | Salmonella enterica subsp. enterica serovar Typhimurium | probably involved in alanine biosynthesis, transaminase C is found at reduced levels upon starvation for any one of several amino acids | L-valine + pyruvate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
K12, strain W3110 | - |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
LT2 strains, avtA gene | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + 3-methyl-2-oxobutanoate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | L-valine + pyruvate | - |
r | |
L-alanine + 3-methyl-2-oxobutanoate | - |
Escherichia coli | L-valine + pyruvate | - |
r | |
L-alanine + 3-methyl-2-oxobutanoate | mutations in the gene encoding this enzyme are silent unless they are combined with mutations involved in isoleucine-valine biosynthesis | Salmonella enterica subsp. enterica serovar Typhimurium | L-valine + pyruvate | - |
r | |
L-alanine + 3-methyl-2-oxobutanoate | mutations in the gene encoding this enzyme are silent unless they are combined with mutations involved in isoleucine-valine biosynthesis | Escherichia coli | L-valine + pyruvate | - |
r | |
L-alanine + 3-methyl-2-oxobutanoate | probably involved in alanine biosynthesis, transaminase C is found at reduced levels upon starvation for any one of several amino acids | Salmonella enterica subsp. enterica serovar Typhimurium | L-valine + pyruvate | - |
r |