Crystallization (Comment) | Organism |
---|---|
in complex with substrate 7-oxo-8-aminopelargonic acid and in complex with inhibitors 1-(1,3-benzothiazol-2-yl)methanamine and 2-hydrazinyl-1,3-benzothiazole. The side chains of Tyr25, Trp65, Arg400, and Tyr407 are shown to be quite flexible. Small molecule binding induces unexpected conformational remodeling in the substrate binding site | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(1,3-benzothiazol-2-yl)methanamine | - |
Mycobacterium tuberculosis | |
2-hydrazinyl-1,3-benzothiazole | reversible covalent inhibitor | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WQ81 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WQ81 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
bioA | - |
Mycobacterium tuberculosis |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
67 | - |
melting temperature, in complex with inhibitor 2-hydrazinyl-1,3-benzothiazole | Mycobacterium tuberculosis |
78 | - |
melting temperature, in complex with inhibitor 1-(1,3-benzothiazol-2-yl)methanamine | Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
2-hydrazinyl-1,3-benzothiazole | pH 8.6, 25°C | Mycobacterium tuberculosis |