BRENDA - Reference to 2.6.1.62; Id = 714208

-

Mycobacterium tuberculosis

to 2.2 A resolution, by molecular replacement, and superimposition of the structures bound either to the S-adenosyl-L-methionine analog sinefungin or to 7-oxo-8-aminopelargonic acid. Comparison to structure of the Bacillus subtilis enzyme, EC 2.5.1.105

Mycobacterium tuberculosis

0.45

-

S-adenosyl-L-methionine

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

0.7

-

sinefungin

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

P9WQ80

-

Mycobacterium tuberculosis CDC 1551

P9WQ80

-

S-adenosyl-L-methionine + 8-amino-7-oxononanoate

-

714208

Mycobacterium tuberculosis

S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

-

?

S-adenosyl-L-methionine + 8-amino-7-oxononanoate

-

714208

Mycobacterium tuberculosis CDC 1551

S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

-

?

S-adenosyl-L-methionine + sinefungin

-

714208

Mycobacterium tuberculosis

S-adenosyl-4-methylthio-2-oxobutanoate + ?

-

?

S-adenosyl-L-methionine + sinefungin

-

714208

Mycobacterium tuberculosis CDC 1551

S-adenosyl-4-methylthio-2-oxobutanoate + ?

-

?

0.009

-

sinefungin

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

0.012

-

S-adenosyl-L-methionine

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

S-adenosyl-L-methionine

-

Mycobacterium tuberculosis

-

Mycobacterium tuberculosis

S-adenosyl-L-methionine

-

Mycobacterium tuberculosis

to 2.2 A resolution, by molecular replacement, and superimposition of the structures bound either to the S-adenosyl-L-methionine analog sinefungin or to 7-oxo-8-aminopelargonic acid. Comparison to structure of the Bacillus subtilis enzyme, EC 2.5.1.105

Mycobacterium tuberculosis

0.45

-

S-adenosyl-L-methionine

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

0.7

-

sinefungin

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

S-adenosyl-L-methionine + 8-amino-7-oxononanoate

-

714208

Mycobacterium tuberculosis

S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

-

?

S-adenosyl-L-methionine + 8-amino-7-oxononanoate

-

714208

Mycobacterium tuberculosis CDC 1551

S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

-

?

S-adenosyl-L-methionine + sinefungin

-

714208

Mycobacterium tuberculosis

S-adenosyl-4-methylthio-2-oxobutanoate + ?

-

?

S-adenosyl-L-methionine + sinefungin

-

714208

Mycobacterium tuberculosis CDC 1551

S-adenosyl-4-methylthio-2-oxobutanoate + ?

-

?

0.009

-

sinefungin

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

0.012

-

S-adenosyl-L-methionine

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

0.013

-

sinefungin

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

0.03

-

S-adenosyl-L-methionine

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

0.013

-

sinefungin

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

0.03

-

S-adenosyl-L-methionine

pH 7.5, temperature not specified in the publication

Mycobacterium tuberculosis

738841

Dai

Fragment-based exploration of ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv

J. Med. Chem.

58

5208-5217

2015

-

1

-

3

-

3

-

1

-

3

-

738054

Dai

Inhibition of Mycobacterium tu ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv

ChemBioChem

15

575-586

2014

-

1

-

2

-

4

-

2

-

1

-

1

-

2

1

-

2

-

721279

Mann

A microplate fluorescence assa ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618

Anal. Biochem.

432

90-96

2013

-

1

-

2

-

7

-

2

-

2

-

2

-

3

2

-

2

-

723412

Cobessi

Biochemical and structural cha ...

Arabidopsis thaliana

Plant Cell

24

1608-1625

2012

-

1

3

-

6

1

-

1

-

7

-

5

2

-

2

-

1

-

1

3

-

6

1

-

1

-

5

2

-

2

-

728182

Shi

Design and synthesis of potent ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618

J. Org. Chem.

77

6051-6058

2012

-

1

-

5

-

1

-

1

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714208

Dey

Structural characterization of ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC 1551

Biochemistry

49

6746-6760

2010

-

1

-

2

-

7

-

4

-

2

-

1

-

1

-

2

-

4

-

2

-

2

702483

Mann

Inhibition of 7,8-diaminopelar ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618

Biochimie

91

826-834

2009

-

1

-

4

-

6

-

3

-

2

8

-

1

-

2

-

4

8

-

3

-

673564

Mann

7,8-Diaminoperlargonic acid am ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618

FEBS J.

273

4778-4789

2006

-

1

-

3

2

-

2

-

8

-

1

-

3

1

-

2

-

1

4

-

1

-

6

4

-

2

-

1

-

3

1

-

2

-

661047

Mann

Inhibition of 7,8-diaminopelar ...

Escherichia coli, Mycobacterium tuberculosis

Biochem. Soc. Trans.

33

802-805

2005

-

1

-

3

-

2

-

2

-

1

-

4

-

2

-

2

3

-

1

2

-

3

-

2

-

1

-

4

-

2

-

661370

Van Arsdell

Removing a bottleneck in the B ...

Bacillus subtilis

Biotechnol. Bioeng.

91

75-83

2005

-

1

-

1

-

1

-

5

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

661088

Sandmark

Conserved and nonconserved res ...

Escherichia coli

Biochemistry

43

1213-1222

2004

-

1

7

-

16

-

1

-

2

-

1

-

3

-

15

1

-

1

-

1

7

-

16

-

1

-

3

-

15

1

-

660565

Eliot

Avoiding the road less travele ...

Escherichia coli

Acc. Chem. Res.

36

757-765

2003

-

1

-

1

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

2

-

663002

Breen

The mechanism of 7,8-diaminope ...

Escherichia coli

Org. Biomol. Chem.

1

3498-3499

2003

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

637095

Eliot

The dual-specific active site ...

Escherichia coli

Biochemistry

41

12582-12589

2002

-

1

-

1

3

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

1

3

-

1

-

2

-

2

-

637097

Käck

Crystal structure of diaminope ...

Escherichia coli

J. Mol. Biol.

291

857-876

1999

-

1

-

1

-

1

-

1

-

1

-

1

-

637096

Käck

Purification and preliminary x ...

Escherichia coli

Acta Crystallogr. Sect. D

54

1397-1398

1998

-

1

-

2

-

1

-

1

-

1335

Izumi

Microbiological biosynthesis o ...

Bacillus roseus, Bacillus roseus IAM 1257, Corynebacterium glutamicum, Kocuria rosea, Salmonella enterica subsp. enterica serovar Typhimurium

Methods Enzymol.

62

326-338

1979

-

9

-

5

-

7

-

1

-

1

-

11

-

1

-

1

-

1

-

1

8

-

8

-

9

-

5

-

1

-

1

-

11

-

1

-

1

-

1

-

1

-

637094

Eisenberg

7,8-Diaminopelargonic acid ami ...

Escherichia coli

Methods Enzymol.

62

342-347

1979

-

5

-

2

-

1

-

1

-

1

3

1

-

1

-

1

-

5

1

5

-

2

-

1

-

1

3

1

-

1

-

637089

Stoner

Purification and properties of ...

Escherichia coli

J. Biol. Chem.

250

4029-4036

1975

-

2

-

1

-

1

-

1

-

7

1

-

1

-

1

-

2

-

1

-

1

-

7

1

-

637090

Izumi

-

Biosynthesis of biotin by micr ...

Bacillus roseus, Bacillus roseus IAM 1257, Corynebacterium glutamicum, Corynebacterium glutamicum NRRL 2311, Escherichia coli, Escherichia coli AKV 0015, Kocuria rosea, Salmonella enterica subsp. enterica serovar Typhimurium

Agric. Biol. Chem.

39

175-181

1975

-

16

5

-

1

8

-

11

-

1

-

20

-

2

1

2

-

2

-

1

10

-

10

-

16

-

5

-

1

8

-

1

-

20

-

2

1

2

-

2

-

1

-

637092

Stoner

Biosynthesis of 7,8-diaminopel ...

Corynebacterium glutamicum, Corynebacterium glutamicum NRRL 2311, Escherichia coli

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250

4037-4043

1975

-

9

4

-

4

-

1

-

2

-

6

-

2

-

1

2

-

4

1

-

4

-

9

1

4

-

2

-

6

-

2

-

1

2

-

637091

Izumi

-

7,8-Diaminopelargonic acid ami ...

Bacillus roseus, Bacillus roseus IAM 1257, Corynebacterium glutamicum, Escherichia coli, Kocuria rosea, Salmonella enterica subsp. enterica serovar Typhimurium

Agric. Biol. Chem.

37

2683-2684

1973

-

6

-

8

-

1

-

3

-

12

-

6

-

1

-

3

-

12

-

Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase

Data extracted from this reference: