Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-Keto-8-aminopelargonic acid | substrate inhibition above 0.1 mM | Corynebacterium glutamicum | |
7-Keto-8-aminopelargonic acid | - |
Escherichia coli | |
As5+ | - |
Corynebacterium glutamicum | |
Ca2+ | - |
Corynebacterium glutamicum | |
Co2+ | 94% inhibition at 1 mM | Corynebacterium glutamicum | |
D-cycloserine | - |
Corynebacterium glutamicum | |
DL-Penicillamine | - |
Corynebacterium glutamicum | |
HgCl2 | 100% inhibition at 1 mM | Corynebacterium glutamicum | |
hydroxylamine | 100% inhibition at 1 mM | Corynebacterium glutamicum | |
iodoacetate | - |
Corynebacterium glutamicum | |
isoniazid | 94% inhibition at 1 mM | Corynebacterium glutamicum | |
KCN | - |
Corynebacterium glutamicum | |
p-chloromercuribenzoate | 100% inhibition at 1 mM | Corynebacterium glutamicum | |
Pb2+ | - |
Corynebacterium glutamicum | |
phenylhydrazine | 100% inhibition at 1 mM | Corynebacterium glutamicum | |
Semicarbazide | 100% inhibition at 1 mM | Corynebacterium glutamicum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00083 | - |
pyridoxal 5'-phosphate | pH 8, 37°C | Corynebacterium glutamicum | |
0.0012 | - |
pyridoxamine 5'-phosphate | pH 8, 37°C | Corynebacterium glutamicum | |
0.069 | - |
8-Amino-7-oxononanoate | pH 8, 37°C | Corynebacterium glutamicum | |
0.55 | - |
S-adenosyl-L-methionine | pH 8, 37°C | Corynebacterium glutamicum | |
1.1 | - |
7-amino-8-oxononanoate | pH 8, 37°C | Corynebacterium glutamicum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
24000 | - |
sedimentation equilibrium method | Corynebacterium glutamicum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | Salmonella enterica subsp. enterica serovar Typhimurium | biotin synthesis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | Escherichia coli | biotin synthesis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | Kocuria rosea | biotin synthesis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | Bacillus roseus | biotin synthesis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | Corynebacterium glutamicum | biotin synthesis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | Escherichia coli AKV 0015 | biotin synthesis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | Corynebacterium glutamicum NRRL 2311 | biotin synthesis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | Bacillus roseus IAM 1257 | biotin synthesis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus roseus | - |
IAM 1257 | - |
Bacillus roseus IAM 1257 | - |
IAM 1257 | - |
Corynebacterium glutamicum | - |
NRRL 2311 | - |
Corynebacterium glutamicum NRRL 2311 | - |
NRRL 2311 | - |
Escherichia coli | - |
AKV 0015 | - |
Escherichia coli AKV 0015 | - |
AKV 0015 | - |
Kocuria rosea | - |
IFO 3764 | - |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
AJ 2635, AJ 2636 | - |
Purification (Comment) | Organism |
---|---|
homogeneity | Corynebacterium glutamicum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 7-amino-8-oxononanoate | 1% of the activity of 8-amino-7-oxononanoate | Escherichia coli | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 7-amino-8-oxononanoate | 1% of the activity of 8-amino-7-oxononanoate | Corynebacterium glutamicum | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 7-amino-8-oxononanoate | 1% of the activity of 8-amino-7-oxononanoate | Escherichia coli AKV 0015 | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 7-amino-8-oxononanoate | 1% of the activity of 8-amino-7-oxononanoate | Corynebacterium glutamicum NRRL 2311 | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | synonym: 7-keto-8-aminopelargonic acid, KAPA | Salmonella enterica subsp. enterica serovar Typhimurium | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | synonym: 7-keto-8-aminopelargonic acid, KAPA | Escherichia coli | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | synonym: 7-keto-8-aminopelargonic acid, KAPA | Kocuria rosea | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | synonym: 7-keto-8-aminopelargonic acid, KAPA | Bacillus roseus | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | synonym: 7-keto-8-aminopelargonic acid, KAPA | Corynebacterium glutamicum | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | biotin synthesis | Salmonella enterica subsp. enterica serovar Typhimurium | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | biotin synthesis | Escherichia coli | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | biotin synthesis | Kocuria rosea | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | biotin synthesis | Bacillus roseus | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | biotin synthesis | Corynebacterium glutamicum | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | synonym: 7-keto-8-aminopelargonic acid, KAPA | Escherichia coli AKV 0015 | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | biotin synthesis | Escherichia coli AKV 0015 | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | synonym: 7-keto-8-aminopelargonic acid, KAPA | Corynebacterium glutamicum NRRL 2311 | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | biotin synthesis | Corynebacterium glutamicum NRRL 2311 | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | synonym: 7-keto-8-aminopelargonic acid, KAPA | Bacillus roseus IAM 1257 | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | biotin synthesis | Bacillus roseus IAM 1257 | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Escherichia coli |
37 | - |
- |
Corynebacterium glutamicum |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | 50 | 25°C: about 65% of activity maximum, 50°C: about 60% of activity maximum | Corynebacterium glutamicum |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
7 | 60 | 10 min, stable | Corynebacterium glutamicum |
70 | - |
10 min, complete loss of activity | Corynebacterium glutamicum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Escherichia coli |
8.5 | - |
- |
Corynebacterium glutamicum |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
7 | 11 | 30 min, stable | Corynebacterium glutamicum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | cofactor | Salmonella enterica subsp. enterica serovar Typhimurium | |
pyridoxal 5'-phosphate | cofactor | Escherichia coli | |
pyridoxal 5'-phosphate | cofactor | Kocuria rosea | |
pyridoxal 5'-phosphate | cofactor | Bacillus roseus | |
pyridoxal 5'-phosphate | cofactor | Corynebacterium glutamicum | |
pyridoxal 5'-phosphate | Km: 0.00083 mM | Corynebacterium glutamicum | |
pyridoxamine 5'-phosphate | Km: 0.0012 mM | Corynebacterium glutamicum | |
pyridoxamine 5'-phosphate | active as cofactor | Salmonella enterica subsp. enterica serovar Typhimurium | |
pyridoxamine 5'-phosphate | active as cofactor | Escherichia coli | |
pyridoxamine 5'-phosphate | active as cofactor | Kocuria rosea | |
pyridoxamine 5'-phosphate | active as cofactor | Bacillus roseus | |
pyridoxamine 5'-phosphate | active as cofactor | Corynebacterium glutamicum |