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Literature summary for 2.6.1.62 extracted from

  • Izumi, Y.; Sato, K.; Tani, Y.; Ogata, K.
    Biosynthesis of biotin by microorganisms. XV. 7,8-Diaminopelargonic acid aminotransferase, an enzyme involved in biotin biosynthesis by microorganisms (1975), Agric. Biol. Chem., 39, 175-181.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
7-Keto-8-aminopelargonic acid substrate inhibition above 0.1 mM Corynebacterium glutamicum
7-Keto-8-aminopelargonic acid
-
Escherichia coli
As5+
-
Corynebacterium glutamicum
Ca2+
-
Corynebacterium glutamicum
Co2+ 94% inhibition at 1 mM Corynebacterium glutamicum
D-cycloserine
-
Corynebacterium glutamicum
DL-Penicillamine
-
Corynebacterium glutamicum
HgCl2 100% inhibition at 1 mM Corynebacterium glutamicum
hydroxylamine 100% inhibition at 1 mM Corynebacterium glutamicum
iodoacetate
-
Corynebacterium glutamicum
isoniazid 94% inhibition at 1 mM Corynebacterium glutamicum
KCN
-
Corynebacterium glutamicum
p-chloromercuribenzoate 100% inhibition at 1 mM Corynebacterium glutamicum
Pb2+
-
Corynebacterium glutamicum
phenylhydrazine 100% inhibition at 1 mM Corynebacterium glutamicum
Semicarbazide 100% inhibition at 1 mM Corynebacterium glutamicum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00083
-
pyridoxal 5'-phosphate pH 8, 37°C Corynebacterium glutamicum
0.0012
-
pyridoxamine 5'-phosphate pH 8, 37°C Corynebacterium glutamicum
0.069
-
8-Amino-7-oxononanoate pH 8, 37°C Corynebacterium glutamicum
0.55
-
S-adenosyl-L-methionine pH 8, 37°C Corynebacterium glutamicum
1.1
-
7-amino-8-oxononanoate pH 8, 37°C Corynebacterium glutamicum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
sedimentation equilibrium method Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 8-amino-7-oxononanoate Salmonella enterica subsp. enterica serovar Typhimurium biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate Escherichia coli biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate Kocuria rosea biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate Bacillus roseus biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate Corynebacterium glutamicum biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate Escherichia coli AKV 0015 biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate Corynebacterium glutamicum NRRL 2311 biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate Bacillus roseus IAM 1257 biotin synthesis S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?

Organism

Organism UniProt Comment Textmining
Bacillus roseus
-
IAM 1257
-
Bacillus roseus IAM 1257
-
IAM 1257
-
Corynebacterium glutamicum
-
NRRL 2311
-
Corynebacterium glutamicum NRRL 2311
-
NRRL 2311
-
Escherichia coli
-
AKV 0015
-
Escherichia coli AKV 0015
-
AKV 0015
-
Kocuria rosea
-
IFO 3764
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
AJ 2635, AJ 2636
-

Purification (Commentary)

Purification (Comment) Organism
homogeneity Corynebacterium glutamicum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 7-amino-8-oxononanoate 1% of the activity of 8-amino-7-oxononanoate Escherichia coli S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 7-amino-8-oxononanoate 1% of the activity of 8-amino-7-oxononanoate Corynebacterium glutamicum S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 7-amino-8-oxononanoate 1% of the activity of 8-amino-7-oxononanoate Escherichia coli AKV 0015 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 7-amino-8-oxononanoate 1% of the activity of 8-amino-7-oxononanoate Corynebacterium glutamicum NRRL 2311 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Escherichia coli S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Kocuria rosea S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Bacillus roseus S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Corynebacterium glutamicum S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Escherichia coli S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Kocuria rosea S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Bacillus roseus S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Corynebacterium glutamicum S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Escherichia coli AKV 0015 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Escherichia coli AKV 0015 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Corynebacterium glutamicum NRRL 2311 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Corynebacterium glutamicum NRRL 2311 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Bacillus roseus IAM 1257 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate biotin synthesis Bacillus roseus IAM 1257 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Escherichia coli
37
-
-
Corynebacterium glutamicum

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 50 25°C: about 65% of activity maximum, 50°C: about 60% of activity maximum Corynebacterium glutamicum

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
7 60 10 min, stable Corynebacterium glutamicum
70
-
10 min, complete loss of activity Corynebacterium glutamicum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Escherichia coli
8.5
-
-
Corynebacterium glutamicum

pH Stability

pH Stability pH Stability Maximum Comment Organism
7 11 30 min, stable Corynebacterium glutamicum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate cofactor Salmonella enterica subsp. enterica serovar Typhimurium
pyridoxal 5'-phosphate cofactor Escherichia coli
pyridoxal 5'-phosphate cofactor Kocuria rosea
pyridoxal 5'-phosphate cofactor Bacillus roseus
pyridoxal 5'-phosphate cofactor Corynebacterium glutamicum
pyridoxal 5'-phosphate Km: 0.00083 mM Corynebacterium glutamicum
pyridoxamine 5'-phosphate Km: 0.0012 mM Corynebacterium glutamicum
pyridoxamine 5'-phosphate active as cofactor Salmonella enterica subsp. enterica serovar Typhimurium
pyridoxamine 5'-phosphate active as cofactor Escherichia coli
pyridoxamine 5'-phosphate active as cofactor Kocuria rosea
pyridoxamine 5'-phosphate active as cofactor Bacillus roseus
pyridoxamine 5'-phosphate active as cofactor Corynebacterium glutamicum